Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate

L Zhao, A Sebkhi, D J Nunez, L Long, C S Haley, J Szpirer, C Szpirer, A J Williams, M R Wilkins

Research output: Contribution to journalArticlepeer-review

Abstract

Fischer 344 (F344) rats are relatively resistant to hypoxia-induced right ventricular (RV) hypertrophy compared with the Wistar-Kyoto (WKY) strain. These 2 strains were used to examine the genetic basis for the differential response.
Original languageEnglish
Pages (from-to)442-7
Number of pages6
JournalCirculation
Volume103
Issue number3
Publication statusPublished - 23 Jan 2001

Keywords

  • Animals
  • Anoxia
  • Body Weight
  • Chromosomes, Human, Pair 17
  • Crosses, Genetic
  • Genetic Linkage
  • Humans
  • Hypertension, Pulmonary
  • Hypertrophy, Right Ventricular
  • In Situ Hybridization, Fluorescence
  • Male
  • Myocardium
  • Organ Size
  • Phenotype
  • Quantitative Trait, Heritable
  • Radioligand Assay
  • Rats
  • Rats, Inbred F344
  • Rats, Inbred WKY
  • Ryanodine Receptor Calcium Release Channel

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