Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate

L Zhao; A Sebkhi; D J Nunez; L Long; C S Haley; J Szpirer; C Szpirer; A J Williams; M R Wilkins

Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate

L Zhao, A Sebkhi, D J Nunez, L Long, C S Haley, J Szpirer, C Szpirer, A J Williams, M R Wilkins

Research output: Contribution to journal › Article › peer-review

Abstract

Fischer 344 (F344) rats are relatively resistant to hypoxia-induced right ventricular (RV) hypertrophy compared with the Wistar-Kyoto (WKY) strain. These 2 strains were used to examine the genetic basis for the differential response.

Original language	English
Pages (from-to)	442-7
Number of pages	6
Journal	Circulation
Volume	103
Issue number	3
Publication status	Published - 23 Jan 2001

Keywords / Materials (for Non-textual outputs)

Animals
Anoxia
Body Weight
Chromosomes, Human, Pair 17
Crosses, Genetic
Genetic Linkage
Humans
Hypertension, Pulmonary
Hypertrophy, Right Ventricular
In Situ Hybridization, Fluorescence
Male
Myocardium
Organ Size
Phenotype
Quantitative Trait, Heritable
Radioligand Assay
Rats
Rats, Inbred F344
Rats, Inbred WKY
Ryanodine Receptor Calcium Release Channel

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title = "Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate",

abstract = "Fischer 344 (F344) rats are relatively resistant to hypoxia-induced right ventricular (RV) hypertrophy compared with the Wistar-Kyoto (WKY) strain. These 2 strains were used to examine the genetic basis for the differential response.",

keywords = "Animals, Anoxia, Body Weight, Chromosomes, Human, Pair 17, Crosses, Genetic, Genetic Linkage, Humans, Hypertension, Pulmonary, Hypertrophy, Right Ventricular, In Situ Hybridization, Fluorescence, Male, Myocardium, Organ Size, Phenotype, Quantitative Trait, Heritable, Radioligand Assay, Rats, Rats, Inbred F344, Rats, Inbred WKY, Ryanodine Receptor Calcium Release Channel",

author = "L Zhao and A Sebkhi and Nunez, \{D J\} and L Long and Haley, \{C S\} and J Szpirer and C Szpirer and Williams, \{A J\} and Wilkins, \{M R\}",

year = "2001",

month = jan,

day = "23",

language = "English",

volume = "103",

pages = "442--7",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

number = "3",

}

TY - JOUR

T1 - Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17

T2 - evaluation of cardiac ryanodine Ryr2 receptor as a candidate

AU - Zhao, L

AU - Sebkhi, A

AU - Nunez, D J

AU - Long, L

AU - Haley, C S

AU - Szpirer, J

AU - Szpirer, C

AU - Williams, A J

AU - Wilkins, M R

PY - 2001/1/23

Y1 - 2001/1/23

N2 - Fischer 344 (F344) rats are relatively resistant to hypoxia-induced right ventricular (RV) hypertrophy compared with the Wistar-Kyoto (WKY) strain. These 2 strains were used to examine the genetic basis for the differential response.

AB - Fischer 344 (F344) rats are relatively resistant to hypoxia-induced right ventricular (RV) hypertrophy compared with the Wistar-Kyoto (WKY) strain. These 2 strains were used to examine the genetic basis for the differential response.

KW - Animals

KW - Anoxia

KW - Body Weight

KW - Chromosomes, Human, Pair 17

KW - Crosses, Genetic

KW - Genetic Linkage

KW - Humans

KW - Hypertension, Pulmonary

KW - Hypertrophy, Right Ventricular

KW - In Situ Hybridization, Fluorescence

KW - Male

KW - Myocardium

KW - Organ Size

KW - Phenotype

KW - Quantitative Trait, Heritable

KW - Radioligand Assay

KW - Rats

KW - Rats, Inbred F344

KW - Rats, Inbred WKY

KW - Ryanodine Receptor Calcium Release Channel

M3 - Article

C2 - 11157698

SN - 0009-7322

VL - 103

SP - 442

EP - 447

JO - Circulation

JF - Circulation

IS - 3

ER -

Right ventricular hypertrophy secondary to pulmonary hypertension is linked to rat chromosome 17: evaluation of cardiac ryanodine Ryr2 receptor as a candidate

Abstract

Keywords / Materials (for Non-textual outputs)

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