Risk factors for antiepileptic drug regimen change in patients with newly diagnosed epilepsy

Marianne C Cunnington, David J Webb, Michael C Irizarry, Ranjani Manjunath

Research output: Contribution to journalArticlepeer-review


This study aimed to investigate the evolution of treatment within patients with newly diagnosed epilepsy identified from a large US commercial health care database. Postdiagnosis, patient follow-up was divided into observation units defined by consecutive antiepileptic drug (AED) prescriptions. Consecutive prescriptions were compared to assess whether a change in AED regimen had occurred. Factors associated with a regimen change were explored using a logistic regression model with subject random effects. Among 5930 patients with newly diagnosed epilepsy, there was a median of one regimen change in the first year. However, patients prescribed polytherapy regimens early in the course of disease were at a substantially greater risk of a regimen change (polytherapy vs monotherapy odds ratio=10.2, 95% confidence interval=9.2-11.3). Although a seizure during the preceding 90 days significantly increased the risk of a regimen change, it was beyond the scope of the study to determine the proportion of changes directly attributable to uncontrolled seizures.
Original languageEnglish
Pages (from-to)168-72
Number of pages5
JournalEpilepsy & Behavior
Issue number2
Publication statusPublished - 2011


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