Projects per year
Abstract
Methods: Participants underwent intelligence testing at age 11 and were followed-up from at 79 years of age.Variables included: age, sex, age 11 IQ, APOE ɛ4, education, diabetes, hypertension, statin use, physical activity at leisure and in occupation, symptoms of depression, height, number of teeth, body mass index, blood pressure,cholesterol and HbA1c. Dementia cases were ascertained from death certificates, electronic patient records and clinical reviews. Logistic regression analysis determined the degree of risk for dementia associated with each variable. Analyses were completed both with and without the physical activity variables due to the significant number of missing data for these variables.
Results: Of the eligible cohort, n = 410 participants remained dementia-free and n = 110 had developed probable dementia. When logistic regression analyses contained all variables, complete data was available for n = 234 (n = 48with dementia). Results demonstrated that positive APOE ɛ4 carrier status (OR: 2.15, 95% CI: 1.04, 4.42) and greater lifetime physical activity (OR: 1.14, 95% CI: 1.02, 1.28) increased the risk for dementia. A reduction in risk for dementia was seen for hypertension (OR: 0.47, 95% CI: 0.23, 0.98). When physical activity variables were excluded,the number with complete data increased to n = 377 (n = 80 with dementia). APOE ɛ4 remained significant(OR: 2.37; 95% CI: 1.37, 4.07), as did hypertension (OR: 0.55; 95% CI: 0.32, 0.93). Conclusions: Dementia incidence was consistent with expected rates. The risk profile for dementia in this cohort of participants aged 79–95 confirmed previous findings that risk factors differ for those over 79 years. Further evidence is recommended in order that the risk profile for this age group can be accurately determined.
Original language | English |
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Article number | 205 |
Pages (from-to) | 1-10 |
Number of pages | 10 |
Journal | BMC Psychiatry |
Volume | 17 |
DOIs | |
Publication status | Published - 2 Jun 2017 |
Keywords / Materials (for Non-textual outputs)
- dementia
- cohort
- incidence
- risk factor
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Dive into the research topics of 'Risk factors for dementia in the ninth decade of life and beyond: A study of the Lothian Birth Cohort 1921'. Together they form a unique fingerprint.Projects
- 3 Finished
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RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I. (Principal Investigator), Gale, C. (Co-investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), Maclullich, A. (Co-investigator), Porteous, D. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator), Wardlaw, J. (Co-investigator) & Okely, J. (Researcher)
1/09/13 → 31/08/19
Project: Research
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Alzheimer Scotland Dementia Research Centre
Russ, T. (Principal Investigator) & Deary, I. (Co-investigator)
16/05/11 → 31/08/18
Project: Research
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A Hundred at Ninety: the common cause Hypothesis of Ageing tested in four waves of the Lothian Birth Cohort 1921
Deary, I. (Principal Investigator), Bates, T. (Co-investigator), Gow, A. (Co-investigator) & Starr, J. (Co-investigator)
UK central government bodies/local authorities, health and hospital authorities
1/01/11 → 31/12/12
Project: Research