TY - JOUR
T1 - Risk factors for developing COVID-19
T2 - a population-based longitudinal study (COVIDENCE UK)
AU - Holt, Hayley
AU - Talaei, Mohammad
AU - Greenig, Matthew
AU - Zenner, Dominik
AU - Symons, Jane
AU - Relton, Clare
AU - Young, Katherine S
AU - Davies, Molly R.
AU - Thompson, Katherine N.
AU - Ashman, Jed
AU - Rajpoot, Sultan Saeed
AU - Ali Kayyale, null
AU - El Rifai, Sarah
AU - Lloyd, Philippa J Lloyd
AU - Jolliffe, David
AU - Timmis, Olivia
AU - Finer, Sarah
AU - Iliodromiti, Stamatina
AU - Miners, Alec
AU - Hopkinson, Nicholas S
AU - Alam, Bodrul
AU - Lloyd-Jones, Graham
AU - Dietrich, Thomas
AU - Chapple, Iain
AU - Pfeffer, Paul E.
AU - McCoy, David
AU - Davies, Gwyneth
AU - Lyons, Ronan A
AU - Griffiths, Christopher
AU - Kee, Frank
AU - Sheikh, Aziz
AU - Breen, Gerome
AU - Shaheen, Seif O
AU - Martineau, Adrian R.
PY - 2021/11/30
Y1 - 2021/11/30
N2 - Background: Risk factors for severe COVID-19 include older age, male sex, obesity, Black or Asian ethnicity and underlying medical conditions. Whether these factors also influence susceptibility to developing COVID-19 is uncertain. Methods: We undertook a prospective, population-based cohort study (COVIDENCE UK) from 1st May 2020 to 5th February 2021. Baseline information on potential risk factors was captured by an online questionnaire. Monthly follow-up questionnaires captured incident COVID-19. We used logistic regression models to estimate multivariable-adjusted odds ratios (aORs) for associations between potential risk factors and odds of COVID-19. Results: We recorded 446 incident cases of COVID-19 in 15,227 participants (2.9%). Increased odds of developing COVID-19 was independently associated with Asian/Asian British vs. White ethnicity (aOR 2.28, 95% CI 1.33-3.91), household overcrowding (aOR per additional 0.5 people/bedroom 1.26, 1.11-1.43), any vs. no visits to/from other households in previous week (aOR 1.31, 1.06-1.62), number of visits to indoor public places (aOR per extra visit per week 1.05, 1.02-1.09), frontline occupation excluding health/social care vs. no frontline occupation (aOR 1.49, 1.12-1.98) and raised body mass index (BMI) (aOR 1.50 [1.19-1.89] for BMI 25.0-30.0 kg/m2 and 1.39 [1.06-1.84] for BMI >30.0 kg/m2 vs. BMI <25.0 kg/m2). Atopic disease was independently associated with decreased odds (aOR 0.75, 0.59-0.97). No independent associations were seen for age, sex, other medical conditions, diet, or micronutrient supplement use.Conclusions: After rigorous adjustment for factors influencing exposure to SARS-CoV-2, Asian/Asian British ethnicity and raised BMI were associated with increased odds of developing COVID-19, while atopic disease was associated with decreased odds.
AB - Background: Risk factors for severe COVID-19 include older age, male sex, obesity, Black or Asian ethnicity and underlying medical conditions. Whether these factors also influence susceptibility to developing COVID-19 is uncertain. Methods: We undertook a prospective, population-based cohort study (COVIDENCE UK) from 1st May 2020 to 5th February 2021. Baseline information on potential risk factors was captured by an online questionnaire. Monthly follow-up questionnaires captured incident COVID-19. We used logistic regression models to estimate multivariable-adjusted odds ratios (aORs) for associations between potential risk factors and odds of COVID-19. Results: We recorded 446 incident cases of COVID-19 in 15,227 participants (2.9%). Increased odds of developing COVID-19 was independently associated with Asian/Asian British vs. White ethnicity (aOR 2.28, 95% CI 1.33-3.91), household overcrowding (aOR per additional 0.5 people/bedroom 1.26, 1.11-1.43), any vs. no visits to/from other households in previous week (aOR 1.31, 1.06-1.62), number of visits to indoor public places (aOR per extra visit per week 1.05, 1.02-1.09), frontline occupation excluding health/social care vs. no frontline occupation (aOR 1.49, 1.12-1.98) and raised body mass index (BMI) (aOR 1.50 [1.19-1.89] for BMI 25.0-30.0 kg/m2 and 1.39 [1.06-1.84] for BMI >30.0 kg/m2 vs. BMI <25.0 kg/m2). Atopic disease was independently associated with decreased odds (aOR 0.75, 0.59-0.97). No independent associations were seen for age, sex, other medical conditions, diet, or micronutrient supplement use.Conclusions: After rigorous adjustment for factors influencing exposure to SARS-CoV-2, Asian/Asian British ethnicity and raised BMI were associated with increased odds of developing COVID-19, while atopic disease was associated with decreased odds.
U2 - 10.1136/thoraxjnl-2021-217487
DO - 10.1136/thoraxjnl-2021-217487
M3 - Article
JO - Thorax
JF - Thorax
SN - 0040-6376
ER -