Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study.

A.J. Rodger, V. Cambiano, T. Bruun, P. Vernazza, S. Collins, O. Degen, G.M. Corbelli, V. Estrada, A.M. Geretti, A. Beloukas, D. Raben, P. Coll, A. Antinori, N. Nwokolo, A. Rieger, J.M. Prins, A. Blaxhult, R. Weber, A. Van Eeden, N.H. BrockmeyerA. Clarke, J. Del Romero Guerrero, F. Raffi, J.R. Bogner, G. Wandeler, J. Gerstoft, F. Gutiérrez, K. Brinkman, M. Kitchen, L. Ostergaard, A. Leon, M. Ristola, H. Jessen, H-J. Stellbrink, A.N. Phillips, J. Lundgren, PARTNER Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: The level of evidence for HIV transmission risk through condomless sex in serodifferent gay couples with the HIV-positive partner taking virally suppressive antiretroviral therapy (ART) is limited compared with the evidence available for transmission risk in heterosexual couples. The aim of the second phase of the PARTNER study (PARTNER2) was to provide precise estimates of transmission risk in gay serodifferent partnerships. METHODS: The PARTNER study was a prospective observational study done at 75 sites in 14 European countries. The first phase of the study (PARTNER1; Sept 15, 2010, to May 31, 2014) recruited and followed up both heterosexual and gay serodifferent couples (HIV-positive partner taking suppressive ART) who reported condomless sex, whereas the PARTNER2 extension (to April 30, 2018) recruited and followed up gay couples only. At study visits, data collection included sexual behaviour questionnaires, HIV testing (HIV-negative partner), and HIV-1 viral load testing (HIV-positive partner). If a seroconversion occurred in the HIV-negative partner, anonymised phylogenetic analysis was done to compare HIV-1 pol and env sequences in both partners to identify linked transmissions. Couple-years of follow-up were eligible for inclusion if condomless sex was reported, use of pre-exposure prophylaxis or post-exposure prophylaxis was not reported by the HIV-negative partner, and the HIV-positive partner was virally suppressed (plasma HIV-1 RNA
Original languageEnglish
JournalThe Lancet
Volume393
Issue number10189
Early online date2 May 2019
DOIs
Publication statusPublished - 15 Jun 2019

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