Abstract
BACKGROUND: The International Parkinson and Movement Disorders Society criteria for mild cognitive impairment in PD need validation. The objectives of this present study were to evaluate prognostic validity of level I (abbreviated) International Parkinson and Movement Disorders Society mild cognitive impairment in PD criteria for development of PD dementia and compared them with level II (comprehensive) criteria.
METHODS: We analyzed data from 8 international studies (1045 patients) from our consortium that included baseline data on demographics, motor signs, depression, detailed neuropsychological testing, and longitudinal follow-up for conversion to Parkinson's disease dementia. Survival analysis evaluated their contribution to the hazard of Parkinson's disease dementia.
RESULTS: Level I mild cognitive impairment in PD, increasing age, male sex, and severity of PD motor signs independently increased the hazard of Parkinson's disease dementia. Level I and level II mild cognitive impairment in PD classification had similar discriminative ability with respect to the time to Parkinson's disease dementia.
CONCLUSIONS: Level I mild cognitive impairment in PD classification independently contributes to the hazard of Parkinson's disease dementia. This finding supports the prognostic validity of the abbreviated mild cognitive impairment in PD criteria. © 2019 International Parkinson and Movement Disorder Society.
| Original language | English |
|---|---|
| Pages (from-to) | 430-435 |
| Number of pages | 6 |
| Journal | Movement Disorders |
| Volume | 34 |
| Issue number | 3 |
| Early online date | 17 Jan 2019 |
| DOIs | |
| Publication status | Published - Mar 2019 |
Keywords / Materials (for Non-textual outputs)
- Age Factors
- Aged
- Cognitive Dysfunction/etiology
- Dementia/etiology
- Female
- Humans
- Male
- Middle Aged
- Neuropsychological Tests
- Parkinson Disease/complications
- Risk Factors
- Sex Factors