Projects per year
Abstract
In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the composition and the structure of the spliceosome are highly dynamic, and eight DExD/H RNA helicases play essential roles in controlling conformational rearrangements. There is evidence that the various helicases are functionally and physically connected with each other and with many other factors in the spliceosome. Understanding the dynamics of those interactions is essential to comprehend the mechanism and regulation of normal as well as of pathological splicing. This review focuses on recent advances in the characterization of the splicing helicases and their interactions, and highlights the deep integration of splicing helicases in global mRNP biogenesis pathways.
Original language | English |
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Pages (from-to) | 83-95 |
Number of pages | 13 |
Journal | Rna biology |
Volume | 10 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Jan 2013 |
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Dive into the research topics of 'RNA helicases in splicing'. Together they form a unique fingerprint.Projects
- 3 Finished
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Core funding renewal for the Wellcome Trust Centre for Cell Biology
1/10/11 → 30/04/17
Project: Research
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Factors that affect the regulation of splicing in Saccharomyces cerevisiae
Beggs, J.
1/01/09 → 31/12/14
Project: Research