RNA helicases in splicing

O. Cordin, J.D. Beggs

Research output: Contribution to journalArticlepeer-review

Abstract

In eukaryotic cells, introns are spliced from pre-mRNAs by the spliceosome. Both the composition and the structure of the spliceosome are highly dynamic, and eight DExD/H RNA helicases play essential roles in controlling conformational rearrangements. There is evidence that the various helicases are functionally and physically connected with each other and with many other factors in the spliceosome. Understanding the dynamics of those interactions is essential to comprehend the mechanism and regulation of normal as well as of pathological splicing. This review focuses on recent advances in the characterization of the splicing helicases and their interactions, and highlights the deep integration of splicing helicases in global mRNP biogenesis pathways.
Original languageEnglish
Pages (from-to)83-95
Number of pages13
JournalRna biology
Volume10
Issue number1
DOIs
Publication statusPublished - 1 Jan 2013

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