RNA-quality control by the exosome

Jonathan Houseley, John LaCava, David Tollervey

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The exosome complex of 3'-> 5' exonucleases is an important component of the RNA-processing machinery in eukaryotes. This complex functions in the accurate processing of nuclear RNA precursors and in the degradation of RNAs in both the nucleus and the cytoplasm. However, it has been unclear how different classes of substrate are distinguished from one another. Recent studies now provide insights into the regulation and structure of the exosome, and they reveal striking similarities between the process of RNA degradation in bacteria and eukaryotes.

Original languageEnglish
Pages (from-to)529-539
Number of pages11
JournalNature reviews Molecular cell biology
Volume7
Issue number7
DOIs
Publication statusPublished - Jul 2006

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