Projects per year
Abstract
The sensing of nucleic acids by receptors of the innate immune system is a key component of antimicrobial immunity. RNA:DNA hybrids, as essential intracellular replication intermediates generated during infection, could therefore represent a class of previously uncharacterised pathogen‐associated molecular patterns sensed by pattern recognition receptors. Here we establish that RNA:DNA hybrids containing viral‐derived sequences efficiently induce pro‐inflammatory cytokine and antiviral type I interferon production in dendritic cells. We demonstrate that MyD88‐dependent signalling is essential for this cytokine response and identify TLR9 as a specific sensor of RNA:DNA hybrids. Hybrids therefore represent a novel molecular pattern sensed by the innate immune system and so could play an important role in host response to viruses and the pathogenesis of autoimmune disease.
Original language | English |
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Pages (from-to) | 542-558 |
Number of pages | 17 |
Journal | EMBO Journal |
Volume | 33 |
Issue number | 6 |
Early online date | 21 Feb 2014 |
DOIs | |
Publication status | Published - 18 Mar 2014 |
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Dive into the research topics of 'RNA:DNA hybrids are a novel molecular pattern sensed by TLR9'. Together they form a unique fingerprint.Projects
- 2 Finished
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Cathelicidins as immunomodulators of host defence against infectious diseases
1/04/11 → 31/03/17
Project: Research
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Orchestration of the th2 response by dendritic cells
MacDonald, A.
1/05/08 → 31/10/13
Project: Research
Profiles
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Karen Mackenzie
- MRC Human Genetics Unit
- Deanery of Molecular, Genetic and Population Health Sciences - ECAT SCREDS Clinical Lecturer in Clinical Genetics
Person: Academic: Research Active