RNAi-mediated chromatin silencing in fission yeast

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract / Description of output

In the fission yeast Schizosaccharomyces pombe, the RNAi pathway plays an important role in the formation and maintenance of heterochromatin. Heterochromatin, or silent chromatin, is an epigenetically inherited attribute of eukaryotic chromosomes which is required for gene regulation, chromosome segregation and maintenance of genome stability. In S. pombe, heterochromatin forms on related repetitive DNA sequences at specific loci. These repetitive sequences, in concert with the RNAi machinery, are thought to attract several proteins including chromatin-modifying enzymes which act to promote heterochromatin formation. The purification of complexes participating in heterochromatin formation has allowed us to begin to analyse in detail the processes involved. In the future this will help us to understand how the RNAi machinery acts to induce the chromatin modifications which lead to heterochromatin assembly in fission yeast.
Original languageEnglish
Title of host publicationCurrent Topics in Microbiology and Immunology
Pages157-183
Number of pages27
Volume320
ISBN (Electronic)978-3-540-75157-1
DOIs
Publication statusPublished - 1 Jan 2008

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume320

Keywords / Materials (for Non-textual outputs)

  • fission yeast
  • H3K9 methylation
  • schizosaccharomyces pombe
  • RNAi pathway
  • heterochromatin formation

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