Robert Feulgen Prize Lecture. Grenzgänger: adult bone marrow cells populate the brain

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

While the brain has traditionally been considered a rather secluded site, recent studies suggest that adult bone marrow (BM)-derived stem cells can generate glia and neurons in rodents and humans. Macrophages and microglia are the first to appear in the murine brain after transplantation of genetically marked BM cells. Within weeks after transplantation, some authors have found astrocytes and cells expressing neuronal antigens. We detected cerebellar Purkinje neurons and interneurons, such as basket cells, expressing the green fluorescent protein (GFP) 10-15 months after transplantation of GFP-labeled BM cells. The results push the boundaries of our classic view of lineage restriction.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalHistochemistry and cell biology
Volume120
Issue number2
DOIs
Publication statusPublished - Aug 2003

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Animals
  • Astrocytes
  • Bone Marrow Transplantation
  • Brain
  • Cell Differentiation
  • Green Fluorescent Proteins
  • Histocytochemistry
  • Humans
  • Luminescent Proteins
  • Mice
  • Microglia
  • Neuronal Plasticity
  • Purkinje Cells
  • Stem Cell Transplantation
  • Transplantation Tolerance
  • Lectures

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