Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae

A Rambukkana, H Yamada, G Zanazzi, T Mathus, J L Salzer, P D Yurchenco, K P Campbell, V A Fischetti

Research output: Contribution to journalArticlepeer-review

Abstract

alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, alpha-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to alpha-DG only in the presence of the G domain of the alpha2 chain of laminin-2. Native alpha-DG competitively inhibited the laminin-2-mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and alpha-DG for its interaction with Schwann cells.

Original languageEnglish
Pages (from-to)2076-9
Number of pages4
JournalScience (New York, N.Y.)
Volume282
Issue number5396
DOIs
Publication statusPublished - 11 Dec 1998

Keywords

  • Animals
  • Bacterial Adhesion
  • Binding Sites
  • Calcium/physiology
  • Cell Line, Transformed
  • Cells, Cultured
  • Cytoskeletal Proteins/metabolism
  • Dystroglycans
  • Edetic Acid/pharmacology
  • Glycosylation
  • Humans
  • Laminin/chemistry
  • Membrane Glycoproteins/metabolism
  • Mycobacterium leprae/metabolism
  • Peripheral Nerves/chemistry
  • Rats
  • Receptors, Laminin/metabolism
  • Recombinant Fusion Proteins/metabolism
  • Recombinant Proteins/chemistry
  • Schwann Cells/metabolism

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