Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Simranpreet Kaur; Liza Jane Raggatt; Lena Batoon; David Arthur Hume; Jean-pierre Levesque; Allison Robyn Pettit

doi:10.1016/j.semcdb.2016.08.009

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Simranpreet Kaur, Liza Jane Raggatt, Lena Batoon, David Arthur Hume, Jean-pierre Levesque, Allison Robyn Pettit

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate anatomically distinct niche environments within these interconnected Tissues. Three bone-bone marrow resident tissue macrophages have been characterised; erythroblastic island macrophages, haematopoietic stem cell niche macrophages and osteal macrophages. The role of these macrophages in controlling homeostasis and repair in bone and bone marrow niches is reviewed in detail.

Original language	English
Pages (from-to)	12-21
Journal	Seminars in Cell and Developmental Biology
Volume	61
Early online date	10 Aug 2016
DOIs	https://doi.org/10.1016/j.semcdb.2016.08.009
Publication status	Published - Jan 2017

Keywords / Materials (for Non-textual outputs)

macrophages
stem cell niches
haematopoiesis
bone and bone marrow

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10.1016/j.semcdb.2016.08.009

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow nichesAccepted author manuscript, 0.99 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND)

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title = "Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches",

abstract = "Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate anatomically distinct niche environments within these interconnected Tissues. Three bone-bone marrow resident tissue macrophages have been characterised; erythroblastic island macrophages, haematopoietic stem cell niche macrophages and osteal macrophages. The role of these macrophages in controlling homeostasis and repair in bone and bone marrow niches is reviewed in detail.",

keywords = "macrophages, stem cell niches, haematopoiesis, bone and bone marrow",

author = "Simranpreet Kaur and Raggatt, \{Liza Jane\} and Lena Batoon and Hume, \{David Arthur\} and Jean-pierre Levesque and Pettit, \{Allison Robyn\}",

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doi = "10.1016/j.semcdb.2016.08.009",

language = "English",

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T1 - Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

AU - Kaur, Simranpreet

AU - Raggatt, Liza Jane

AU - Batoon, Lena

AU - Hume, David Arthur

AU - Levesque, Jean-pierre

AU - Pettit, Allison Robyn

PY - 2017/1

Y1 - 2017/1

N2 - Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate anatomically distinct niche environments within these interconnected Tissues. Three bone-bone marrow resident tissue macrophages have been characterised; erythroblastic island macrophages, haematopoietic stem cell niche macrophages and osteal macrophages. The role of these macrophages in controlling homeostasis and repair in bone and bone marrow niches is reviewed in detail.

AB - Macrophages, named for their phagocytic ability, participate in homeostasis, tissue regeneration and inflammatory responses. Bone and adjacent marrow contain multiple functionally unique resident tissue macrophage subsets which maintain and regulate anatomically distinct niche environments within these interconnected Tissues. Three bone-bone marrow resident tissue macrophages have been characterised; erythroblastic island macrophages, haematopoietic stem cell niche macrophages and osteal macrophages. The role of these macrophages in controlling homeostasis and repair in bone and bone marrow niches is reviewed in detail.

KW - macrophages

KW - stem cell niches

KW - haematopoiesis

KW - bone and bone marrow

U2 - 10.1016/j.semcdb.2016.08.009

DO - 10.1016/j.semcdb.2016.08.009

M3 - Article

SN - 1084-9521

VL - 61

SP - 12

EP - 21

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -

Role of bone marrow macrophages in controlling homeostasis and repair in bone and bone marrow niches

Abstract

Keywords / Materials (for Non-textual outputs)

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