TY - JOUR
T1 - Role of cannabinoid receptors in bone disorders
T2 - alternatives for treatment
AU - Idris, Aymen I
N1 - Copyright 2008 Prous Science, S.A.U. or its licensors. All rights reserved.
PY - 2008/12
Y1 - 2008/12
N2 - A number of recent preclinical studies have demonstrated the potential role of cannabinoids and their receptors in bone metabolism. Pharmacological and genetic modulation of cannabinoid receptors indicate that cannabinoid ligands may provide attractive and novel agents for the treatment of bone diseases. This article reviews the role of cannabinoid receptors in regulating bone mass, bone loss and bone cell function in health and disease. The article also provides support to the notion that cannabinoid receptor ligands show a great promise in the treatment of bone diseases associated with accelerated osteoclastic bone resorption including osteoporosis, rheumatoid arthritis and bone metastasis.
AB - A number of recent preclinical studies have demonstrated the potential role of cannabinoids and their receptors in bone metabolism. Pharmacological and genetic modulation of cannabinoid receptors indicate that cannabinoid ligands may provide attractive and novel agents for the treatment of bone diseases. This article reviews the role of cannabinoid receptors in regulating bone mass, bone loss and bone cell function in health and disease. The article also provides support to the notion that cannabinoid receptor ligands show a great promise in the treatment of bone diseases associated with accelerated osteoclastic bone resorption including osteoporosis, rheumatoid arthritis and bone metastasis.
UR - http://www.scopus.com/inward/record.url?scp=62649160576&partnerID=8YFLogxK
U2 - 10.1358/dnp.2008.21.10.1314055
DO - 10.1358/dnp.2008.21.10.1314055
M3 - Literature review
C2 - 19221634
SN - 0214-0934
VL - 21
SP - 533
EP - 540
JO - Drug News & Perspectives
JF - Drug News & Perspectives
IS - 10
ER -