Role of DISC1 in neural development and schizophrenia

S. Mackie; J. K. Millar; D. J. Porteous

doi:10.1016/j.conb.2007.01.007

Role of DISC1 in neural development and schizophrenia

S. Mackie, J. K. Millar, D. J. Porteous

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

How can we hope to explain mechanistically the schizophrenic phenotype? Perhaps through the reductionist approach of genetics, which is beginning to yield biological clues. Growing evidence supports the view that the well-established genetic risk factor DISC1 plays an important role in schizophrenia biology by interacting with FEZ1 and NDEL1 during neurodevelopment and with the phosphodiesterase PDE4B in neuronal cell signalling. Thus, DISC1 and its pathways support the neurodevelopmental hypothesis of schizophrenia and provide a mechanistic explanation for the characteristic cognitive deficits. Genetic variants of DISC1 also predispose to related affective (mood) disorders. As a consequence, we can speculate on the mechanisms of DISC1 action and possible routes to treatment for these common, debilitating brain disorders.

Original language	English
Pages (from-to)	95-102
Number of pages	8
Journal	Current Opinion in Neurobiology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1016/j.conb.2007.01.007
Publication status	Published - 2007

Keywords / Materials (for Non-textual outputs)

3',5'-Cyclic-AMP Phosphodiesterases/genetics/metabolism Animals Brain/*embryology/*growth & development/metabolism Carrier Proteins/genetics/metabolism Cyclic Nucleotide Phosphodiesterases, Type 4 DNA-Binding Proteins/genetics/metabolism Gene Expression Regulation, Developmental/genetics Genetic Predisposition to Disease/*genetics Humans Models, Neurological Nerve Tissue Proteins/genetics/*metabolism Schizophrenia/genetics/metabolism/*physiopathology Tumor Suppressor Proteins/genetics/metabolism

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title = "Role of DISC1 in neural development and schizophrenia",

abstract = "How can we hope to explain mechanistically the schizophrenic phenotype? Perhaps through the reductionist approach of genetics, which is beginning to yield biological clues. Growing evidence supports the view that the well-established genetic risk factor DISC1 plays an important role in schizophrenia biology by interacting with FEZ1 and NDEL1 during neurodevelopment and with the phosphodiesterase PDE4B in neuronal cell signalling. Thus, DISC1 and its pathways support the neurodevelopmental hypothesis of schizophrenia and provide a mechanistic explanation for the characteristic cognitive deficits. Genetic variants of DISC1 also predispose to related affective (mood) disorders. As a consequence, we can speculate on the mechanisms of DISC1 action and possible routes to treatment for these common, debilitating brain disorders.",

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author = "S. Mackie and Millar, {J. K.} and Porteous, {D. J.}",

note = "Feb Role of DISC1 in neural development and schizophrenia Journal Article Research Support, Non-U.S. Gov't Review England eng",

year = "2007",

doi = "10.1016/j.conb.2007.01.007",

language = "English",

volume = "17",

pages = "95--102",

journal = "Current Opinion in Neurobiology",

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TY - JOUR

T1 - Role of DISC1 in neural development and schizophrenia

AU - Mackie, S.

AU - Millar, J. K.

AU - Porteous, D. J.

N1 - Feb Role of DISC1 in neural development and schizophrenia Journal Article Research Support, Non-U.S. Gov't Review England eng

PY - 2007

Y1 - 2007

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AB - How can we hope to explain mechanistically the schizophrenic phenotype? Perhaps through the reductionist approach of genetics, which is beginning to yield biological clues. Growing evidence supports the view that the well-established genetic risk factor DISC1 plays an important role in schizophrenia biology by interacting with FEZ1 and NDEL1 during neurodevelopment and with the phosphodiesterase PDE4B in neuronal cell signalling. Thus, DISC1 and its pathways support the neurodevelopmental hypothesis of schizophrenia and provide a mechanistic explanation for the characteristic cognitive deficits. Genetic variants of DISC1 also predispose to related affective (mood) disorders. As a consequence, we can speculate on the mechanisms of DISC1 action and possible routes to treatment for these common, debilitating brain disorders.

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JO - Current Opinion in Neurobiology

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ER -

Role of DISC1 in neural development and schizophrenia

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