Role of ErbB2 in selection for adjuvant tamoxifen or aromatase inhibitors

Mr J Michael Dixon, MIchael Dixon

Research output: Contribution to journalArticlepeer-review


Evaluation of: Rasmussen BB, Regan MM, Lykkesfeldt AE et al.: Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomized trial. Lancet Oncol. 9, 23-28 (2008). This study analysed data after a median of 51 months follow-up from 4922 postmenopausal women with early hormone-sensitive breast cancer randomly assigned to 5 years of treatment with letrozole or tamoxifen. Tumors from 3650 (74%) patients were centrally assessed for estrogen receptor, progesterone receptor and ErbB2 status. By central assessment, 7% (257 of 3650) of tumors were classified as ErbB2-positive. Disease-free survival was significantly worse in patients with ErbB2-positive tumors (p
Original languageEnglish
Pages (from-to)229-31
Number of pages3
JournalWomen's Health
Issue number3
Publication statusPublished - May 2008


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