Role of human tissue kallikrein in gastrointestinal stromal tumour invasion

P Dominek, P Campagnolo, M H-Zadeh, N Kränkel, M Chilosi, J A Sharman, A Caporali, G Mangialardi, G Spinetti, C Emanueli, M Pignatelli, P Madeddu

Research output: Contribution to journalArticlepeer-review

Abstract

Human tissue kallikrein (hK1) generates vasodilator kinins from kininogen and promotes angiogenesis by kinin-dependent and kinin-independent mechanisms. Here, we investigate the expression and functional relevance of hK1 in human gastrointestinal stromal tumour (GIST).
Original languageEnglish
Pages (from-to)1422-31
Number of pages10
JournalBritish Journal of Cancer
Volume103
Issue number9
DOIs
Publication statusPublished - 26 Oct 2010

Keywords

  • Animals
  • Cell Line, Tumor
  • Cell Movement
  • Female
  • Gastrointestinal Stromal Tumors
  • Humans
  • Male
  • Mice
  • Mice, Nude
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Transplantation
  • Tissue Kallikreins

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