Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy

Mhairi C Donnelly; Peter C Hayes; Kenneth J Simpson

doi:10.3748/wjg.v22.i26.5958

Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy

Mhairi C Donnelly, Peter C Hayes, Kenneth J Simpson

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multi-organ failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research.

Original language	English
Pages (from-to)	5958-70
Number of pages	13
Journal	World Journal of Gastroenterology
Volume	22
Issue number	26
Early online date	14 Jul 2016
DOIs	https://doi.org/10.3748/wjg.v22.i26.5958
Publication status	E-pub ahead of print - 14 Jul 2016

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10.3748/wjg.v22.i26.5958

WJG-22-5958
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Final published version, 1.26 MBLicence: Creative Commons: Attribution Non-Commercial (CC-BY-NC)

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title = "Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy",

abstract = "Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multi-organ failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research.",

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AU - Simpson, Kenneth J

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Y1 - 2016/7/14

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AB - Acute liver failure is a rare and devastating clinical condition. At present, emergency liver transplantation is the only life-saving therapy in advanced cases, yet the feasibility of transplantation is affected by the presence of systemic inflammation, infection and resultant multi-organ failure. The importance of immune dysregulation and acquisition of infection in the pathogenesis of acute liver failure and its associated complications is now recognised. In this review we discuss current thinking regarding the role of infection and inflammation in the pathogenesis of and outcome in human acute liver failure, the implications for the management of such patients and suggest directions for future research.

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DO - 10.3748/wjg.v22.i26.5958

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JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 26

ER -

Role of inflammation and infection in the pathogenesis of human acute liver failure: Clinical implications for monitoring and therapy

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