Abstract / Description of output
Ageing is defined as a progressive decline of homeostasis that occurs after the reproductive phase of life is complete, which is thought to arise because of impaired DNA repair following damage. This leads to an increased risk of disease or death. Ageing is one of the most important risk factors for most chronic diseases. Chronic obstructive pulmonary disease (COPD) represents an important component of the increasingly prevalent multiple chronic debilitating diseases that are a major cause of morbidity and mortality, particularly in the elderly. There is increasing evidence that the pathogenesis of COPD is linked to an accelerated ageing process. This review discusses the evidence supporting a number of mechanisms, including oxidative stress and ageing, in the pathogenesis of COPD. Greater understanding of these mechanisms leads to novel therapeutic interventions targeted at this heterogeneous disease.
Original language | English |
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Pages (from-to) | 122-135 |
Number of pages | 14 |
Journal | COPD: Journal of Chronic Obstructive Pulmonary Disease |
Volume | 14 |
Issue number | 1 |
Early online date | 13 Sept 2016 |
DOIs | |
Publication status | Published - Feb 2017 |
Keywords / Materials (for Non-textual outputs)
- Aging
- Anti-Inflammatory Agents
- Antioxidants
- Apoptosis
- Autophagy
- Cellular Senescence
- Glycation End Products, Advanced
- Humans
- Inflammation
- Lung
- Mitochondria
- NF-kappa B
- Oxidative Stress
- Pulmonary Disease, Chronic Obstructive
- Reactive Nitrogen Species
- Reactive Oxygen Species
- Sirtuins
- Telomere Shortening
- Unfolded Protein Response
- Journal Article
- Review