Role of inflammatory mediators in human endometrium during progesterone withdrawal and early pregnancy

H O Critchley, R L Jones, R G Lea, T A Drudy, R W Kelly, Alistair Williams, D T Baird

Research output: Contribution to journalArticlepeer-review


The role of progesterone (P4) in the regulation of inflammatory mediators interleukin-8 (IL-8), monocyte chemoattractant protein-1, and cyclooxygenase-2 (COX-2) and in the recruitment of leukocyte subpopulations in the endometrium has been examined, by employing a model of P4 withdrawal and maintenance in vivo. Messenger RNA and protein expression have been investigated in endometrial biopsies: 1) during the midsecretory phase (LH+8 to 10); during the maintained luteal phase (P4 administered vaginally for 4 days from LH+8) and biopsies collected 2) 24 h and 3) 48 h post withdrawal of P4; and 4) during pseudo pregnancy (lifespan of corpus luteum extended by 7 days with CG; (decidua collected from women with 5) an ectopic gestation and 6) from women undergoing first-trimester termination of pregnancy). CD56+ large granular lymphocytes remain the major leukocyte subtype, both 24 and 48 h after P4 withdrawal, and in decidua (CG supported or ectopic). Higher numbers (P
Original languageEnglish
Pages (from-to)240-8
Number of pages9
JournalJournal of Clinical Endocrinology & Metabolism
Issue number1
Publication statusPublished - Jan 1999


  • Chemokine CCL2
  • Cyclooxygenase 2
  • Dinoprost
  • Endometrium
  • Enzyme-Linked Immunosorbent Assay
  • Estradiol
  • Female
  • Humans
  • Immunohistochemistry
  • Inflammation Mediators
  • Interleukin-8
  • Isoenzymes
  • Leukocytes
  • Membrane Proteins
  • Pregnancy
  • Progesterone
  • Prostaglandin-Endoperoxide Synthases
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction

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