Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting

Heather M Marshall, Keshet Ronen, Charles Berry, Manuel Llano, Heidi Sutherland, Dyana Saenz, Wendy Bickmore, Eric Poeschla, Frederic D Bushman

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

To replicate, lentiviruses such as HIV must integrate DNA copies of their RNA genomes into host cell chromosomes. Lentiviral integration is favored in active transcription units, which allows efficient viral gene expression after integration, but the mechanisms directing integration targeting are incompletely understood. A cellular protein, PSIP1/LEDGF/p75, binds tightly to the lentiviral-encoded integrase protein (IN), and has been reported to be important for HIV infectivity and integration targeting.
Original languageEnglish
Pages (from-to)e1340
JournalPLoS ONE
Issue number12
Publication statusPublished - 2007

Keywords / Materials (for Non-textual outputs)

  • Adaptor Proteins, Signal Transducing
  • Animals
  • Cell Line
  • Consensus Sequence
  • HIV
  • Humans
  • Infectious Anemia Virus, Equine
  • Mice
  • Transcription Factors
  • Virulence
  • Virus Integration


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