Role of the HLA System in the Association Between Multiple Sclerosis and Infectious Mononucleosis

Sreeram V. Ramagopalan; Ute C. Meier; Margaret Conacher; George C. Ebers; Gavin Giovannoni; Dorothy H. Crawford; Karen A. McAulay

doi:10.1001/archneurol.2011.48

Role of the HLA System in the Association Between Multiple Sclerosis and Infectious Mononucleosis

Sreeram V. Ramagopalan, Ute C. Meier, Margaret Conacher, George C. Ebers, Gavin Giovannoni, Dorothy H. Crawford, Karen A. McAulay

Deanery of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Objective: To determine whether multiple sclerosis (MS) and infectious mononucleosis (IM) share common HLA associations.

Design: A prospective cohort study was conducted from October 1, 1999, through September 30, 2003.

Setting: University of Edinburgh Richard Verney Health Centre, Edinburgh, Scotland.

Patients: Participants included 179 individuals who underwent asymptomatic Epstein-Barr virus seroconversion and 175 patients who developed IM.

Intervention: Genotyping for 5 classical HLA loci (HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1).

Main Outcome Measure: Diagnosis of IM and allele frequency.

Results: Allelic analysis showed that HLA-DRB1*01:01 was significantly associated with the development of IM (odds ratio, 3.2; P < .001). Patients with IM and HLA-DRB1*01:01 had a lower Epstein-Barr virus viral load compared with those without the allele (median, 783 vs 7366 copies/10(6) peripheral blood mononuclear cells; P = .03).

Conclusion: HLA-DRB1*01:01 is protective against developing MS; thus, a common genetic basis between IM and MS is not supported.

Original language	English
Pages (from-to)	469-472
Number of pages	4
Journal	Archives of Neurology
Volume	68
Issue number	4
DOIs	https://doi.org/10.1001/archneurol.2011.48
Publication status	Published - Apr 2011

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http://archneur.ama-assn.org/cgi/content/abstract/68/4/469

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title = "Role of the HLA System in the Association Between Multiple Sclerosis and Infectious Mononucleosis",

abstract = "Objective: To determine whether multiple sclerosis (MS) and infectious mononucleosis (IM) share common HLA associations.Design: A prospective cohort study was conducted from October 1, 1999, through September 30, 2003.Setting: University of Edinburgh Richard Verney Health Centre, Edinburgh, Scotland.Patients: Participants included 179 individuals who underwent asymptomatic Epstein-Barr virus seroconversion and 175 patients who developed IM.Intervention: Genotyping for 5 classical HLA loci (HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1).Main Outcome Measure: Diagnosis of IM and allele frequency.Results: Allelic analysis showed that HLA-DRB1*01:01 was significantly associated with the development of IM (odds ratio, 3.2; P < .001). Patients with IM and HLA-DRB1*01:01 had a lower Epstein-Barr virus viral load compared with those without the allele (median, 783 vs 7366 copies/10(6) peripheral blood mononuclear cells; P = .03).Conclusion: HLA-DRB1*01:01 is protective against developing MS; thus, a common genetic basis between IM and MS is not supported.",

author = "Ramagopalan, {Sreeram V.} and Meier, {Ute C.} and Margaret Conacher and Ebers, {George C.} and Gavin Giovannoni and Crawford, {Dorothy H.} and McAulay, {Karen A.}",

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language = "English",

volume = "68",

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AU - Ramagopalan, Sreeram V.

AU - Meier, Ute C.

AU - Conacher, Margaret

AU - Ebers, George C.

AU - Giovannoni, Gavin

AU - Crawford, Dorothy H.

AU - McAulay, Karen A.

PY - 2011/4

Y1 - 2011/4

N2 - Objective: To determine whether multiple sclerosis (MS) and infectious mononucleosis (IM) share common HLA associations.Design: A prospective cohort study was conducted from October 1, 1999, through September 30, 2003.Setting: University of Edinburgh Richard Verney Health Centre, Edinburgh, Scotland.Patients: Participants included 179 individuals who underwent asymptomatic Epstein-Barr virus seroconversion and 175 patients who developed IM.Intervention: Genotyping for 5 classical HLA loci (HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1).Main Outcome Measure: Diagnosis of IM and allele frequency.Results: Allelic analysis showed that HLA-DRB1*01:01 was significantly associated with the development of IM (odds ratio, 3.2; P < .001). Patients with IM and HLA-DRB1*01:01 had a lower Epstein-Barr virus viral load compared with those without the allele (median, 783 vs 7366 copies/10(6) peripheral blood mononuclear cells; P = .03).Conclusion: HLA-DRB1*01:01 is protective against developing MS; thus, a common genetic basis between IM and MS is not supported.

AB - Objective: To determine whether multiple sclerosis (MS) and infectious mononucleosis (IM) share common HLA associations.Design: A prospective cohort study was conducted from October 1, 1999, through September 30, 2003.Setting: University of Edinburgh Richard Verney Health Centre, Edinburgh, Scotland.Patients: Participants included 179 individuals who underwent asymptomatic Epstein-Barr virus seroconversion and 175 patients who developed IM.Intervention: Genotyping for 5 classical HLA loci (HLA-A, HLA-B, HLA-C, HLA-DRB1, and HLA-DQB1).Main Outcome Measure: Diagnosis of IM and allele frequency.Results: Allelic analysis showed that HLA-DRB1*01:01 was significantly associated with the development of IM (odds ratio, 3.2; P < .001). Patients with IM and HLA-DRB1*01:01 had a lower Epstein-Barr virus viral load compared with those without the allele (median, 783 vs 7366 copies/10(6) peripheral blood mononuclear cells; P = .03).Conclusion: HLA-DRB1*01:01 is protective against developing MS; thus, a common genetic basis between IM and MS is not supported.

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DO - 10.1001/archneurol.2011.48

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JO - Archives of Neurology

JF - Archives of Neurology

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ER -

Role of the HLA System in the Association Between Multiple Sclerosis and Infectious Mononucleosis

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