Roles of centromeres and kinetochores in meiosis

Adele L. Marston*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Meiosis is the cell division process by which haploid gametes are produced from a diploid progenitor cell. Reduction of the genome by half requires that DNA replication is followed not by one nuclear division, as in mitosis, but by two consecutive divisions. The sorting and segregation of chromosomes during these two nuclear divisions is tightly controlled, thereby ensuring that each of the gametes inherits a complete haploid set of chromosomes. Errors in chromosome segregation during meiosis generate gametes with too few or too many chromosomes, a condition known as aneuploidy, which is associated with birth defects and infertility (Hassold and Hunt, 2001). This chapter reviews our current understanding of the role the centromere and kinetochore play in bringing about the specialized segregation of chromosomes during meiosis.

Original languageEnglish
Title of host publicationThe Kinetochore
Subtitle of host publicationFrom Molecular Discoveries to Cancer Therapy
PublisherSpringer New York
Pages395-431
Number of pages37
ISBN (Electronic)978-0-387-69076-6
ISBN (Print)9780387690735
DOIs
Publication statusPublished - 1 Dec 2009

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