ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

Pierpaola Davalli, Tijana Mitic, Andrea Caporali, Angela Lauriola, Domenico D'Arca

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

The aging process worsens the human body functions at multiple levels, thus causing its gradual decrease to resist stress, damage, and disease. Besides changes in gene expression and metabolic control, the aging rate has been associated with the production of high levels of Reactive Oxygen Species (ROS) and/or Reactive Nitrosative Species (RNS). Specific increases of ROS level have been demonstrated as potentially critical for induction and maintenance of cell senescence process. Causal connection between ROS, aging, age-related pathologies, and cell senescence is studied intensely. Senescent cells have been proposed as a target for interventions to delay the aging and its related diseases or to improve the diseases treatment. Therapeutic interventions towards senescent cells might allow restoring the health and curing the diseases that share basal processes, rather than curing each disease in separate and symptomatic way. Here, we review observations on ROS ability of inducing cell senescence through novel mechanisms that underpin aging processes. Particular emphasis is addressed to the novel mechanisms of ROS involvement in epigenetic regulation of cell senescence and aging, with the aim to individuate specific pathways, which might promote healthy lifespan and improve aging.

Original languageEnglish
Pages (from-to)3565127
JournalOxidative Medicine and Cellular Longevity
Publication statusPublished - 6 Apr 2016


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