Rosavirus: the prototype of a proposed new genus of the Picornaviridae family

Tung Gia Phan, Nguyen Phung Vo, Peter Simmonds, Erik Samayoa, Samia Naccache, Charles Y Chiu, Eric Delwart

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

We describe a 8,724-nucleotide-long picornavirus genome encoding a single 2,470-aa polyprotein obtained from the feces of a wild mouse. Rosavirus is genetically closest to the double ORF Dicipivirus found in canine feces that is currently the only picornavirus with a second internal ribosome entry site (IRES). Of note, a section of rosavirus' 5'UTR showed strong sequence and structural conservation with the type II IRES from the Parechovirus and Hungarovirus genera possibly reflecting exchange of genetic modules between genera. Based on genetic distance criteria rosavirus qualifies as prototype of a new genus of the Picornaviridae family.
Original languageEnglish
Pages (from-to)556-558
JournalVirus Genes
Issue number3
Early online date13 Aug 2013
Publication statusPublished - Dec 2013


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