Runs of homozygosity do not influence survival to old age

Maris Kuningas; Ruth McQuillan; James F Wilson; Albert Hofman; Cornelia M van Duijn; André G Uitterlinden; Henning Tiemeier

doi:10.1371/journal.pone.0022580

Runs of homozygosity do not influence survival to old age

Maris Kuningas, Ruth McQuillan, James F Wilson, Albert Hofman, Cornelia M van Duijn, André G Uitterlinden, Henning Tiemeier

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.

Original language	English
Pages (from-to)	e22580
Journal	PLoS ONE
Volume	6
Issue number	7
DOIs	https://doi.org/10.1371/journal.pone.0022580
Publication status	Published - 2011

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10.1371/journal.pone.0022580

Runs of homozygosity do not influence survival to old age
Copyright: © 2011 Kuningas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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title = "Runs of homozygosity do not influence survival to old age",

abstract = "Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.",

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AU - Kuningas, Maris

AU - McQuillan, Ruth

AU - Wilson, James F

AU - Hofman, Albert

AU - van Duijn, Cornelia M

AU - Uitterlinden, André G

AU - Tiemeier, Henning

PY - 2011

Y1 - 2011

N2 - Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.

AB - Runs of homozygosity (ROH) are extended tracts of adjacent homozygous single nucleotide polymorphisms (SNPs) that are more common in unrelated individuals than previously thought. It has been proposed that estimating ROH on a genome-wide level, by making use of the genome-wide single nucleotide polymorphism (SNP) data, will enable to indentify recessive variants underlying complex traits. Here, we examined ROH larger than 1.5 Mb individually and in combination for association with survival in 5974 participants of the Rotterdam Study. In addition, we assessed the role of overall homozygosity, expressed as a percentage of the autosomal genome that is in ROH longer than 1.5 Mb, on survival during a mean follow-up period of 12 years. None of these measures of homozygosity was associated with survival to old age.

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DO - 10.1371/journal.pone.0022580

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SP - e22580

JO - PLoS ONE

JF - PLoS ONE

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ER -

Runs of homozygosity do not influence survival to old age

Abstract / Description of output

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