Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Suvankar Pal; Jeremy Chataway; Robert Swingler; Malcolm R Macleod; Neil O Carragher; Giles Hardingham; Bhuvaneish Thangaraj Selvaraj; Colin Smith; Charis Wong; Judith Newton; Dawn Lyle; Amy Stenson; Rachel S Dakin; Amarachi Ihenacho; Shuna Colville; Arpan R Mehta; Nigel Stallard; James R Carpenter; Richard A Parker; Catriona Keerie; Christopher J Weir; Bruce Virgo; Stevie Morris; Nicola Waters; Beverley Gray; Donald Macdonald; Euan Macdonald; Mahesh K B Parmar; Siddharthan Chandran; MND SMART Investigators

doi:10.1016/S1474-4422(24)00326-0

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

Suvankar Pal^*, Jeremy Chataway, Robert Swingler, Malcolm R Macleod, Neil O Carragher, Giles Hardingham, Bhuvaneish Thangaraj Selvaraj, Colin Smith, Charis Wong, Judith Newton, Dawn Lyle, Amy Stenson, Rachel S Dakin, Amarachi Ihenacho, Shuna Colville, Arpan R Mehta, Nigel Stallard, James R Carpenter, Richard A Parker, Catriona KeerieChristopher J Weir, Bruce Virgo, Stevie Morris, Nicola Waters, Beverley Gray, Donald Macdonald, Euan Macdonald, Mahesh K B Parmar, Siddharthan Chandran, MND SMART Investigators

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1097-1107
Journal	The Lancet Neurology
Volume	23
Issue number	11
Early online date	19 Sept 2024
DOIs	https://doi.org/10.1016/S1474-4422(24)00326-0
Publication status	Published - 1 Nov 2024

Access to Document

10.1016/S1474-4422(24)00326-0Licence: CC BY

Safety-and-efficacy-of-memantine-and-trazodone-verFinal published version, 734 KBLicence: Creative Commons: Attribution (CC-BY)

https://linkinghub.elsevier.com/retrieve/pii/S1474442224003260

Cite this

Pal, S., Chataway, J., Swingler, R., Macleod, M. R., Carragher, N. O., Hardingham, G., Selvaraj, B. T., Smith, C., Wong, C., Newton, J., Lyle, D., Stenson, A., Dakin, R. S., Ihenacho, A., Colville, S., Mehta, A. R., Stallard, N., Carpenter, J. R., Parker, R. A., ... MND SMART Investigators (2024). Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial. The Lancet Neurology, 23(11), 1097-1107. https://doi.org/10.1016/S1474-4422(24)00326-0

@article{c6b475e99593435089d6a84035fdfe7e,

title = "Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial",

author = "Suvankar Pal and Jeremy Chataway and Robert Swingler and Macleod, {Malcolm R} and Carragher, {Neil O} and Giles Hardingham and Selvaraj, {Bhuvaneish Thangaraj} and Colin Smith and Charis Wong and Judith Newton and Dawn Lyle and Amy Stenson and Dakin, {Rachel S} and Amarachi Ihenacho and Shuna Colville and Mehta, {Arpan R} and Nigel Stallard and Carpenter, {James R} and Parker, {Richard A} and Catriona Keerie and Weir, {Christopher J} and Bruce Virgo and Stevie Morris and Nicola Waters and Beverley Gray and Donald Macdonald and Euan Macdonald and Parmar, {Mahesh K B} and Siddharthan Chandran and {MND SMART Investigators} and George Gorrie and Ian Morrison and Callum Duncan and {Carod artal}, Javier and Timothy Williams and Venkataramanan Srinivasan and Aleksandar Radunovic and Ashwin Pinto and Hisham Hamdalla and Rhys Roberts and {Garcia- reitboeck}, Pablo and Timothy Harrower and Godwin Mamutse and Francesca Crawley and Clare Galton and Kenneth Dawson and Raeburn Forbes and Charles Hillier and Christopher Mcdermott and Deborah Forbes and Hatice Bozkurt and Maria Stavrou and Patrick Kearns and David Breen and {Kurucu king}, Hatice and Elizabeth Elliot and Emily Beswick and Jill Williamson and Paolo Cucurachi and Lucy Mclennan",

year = "2024",

month = nov,

day = "1",

doi = "10.1016/S1474-4422(24)00326-0",

language = "English",

volume = "23",

pages = "1097--1107",

journal = "The Lancet Neurology",

issn = "1474-4422",

publisher = "Elsevier Science",

number = "11",

}

Pal, S, Chataway, J, Swingler, R, Macleod, MR , Carragher, NO , Hardingham, G , Selvaraj, BT , Smith, C , Wong, C, Newton, J, Lyle, D, Stenson, A, Dakin, RS, Ihenacho, A, Colville, S, Mehta, AR, Stallard, N, Carpenter, JR, Parker, RA , Keerie, C , Weir, CJ, Virgo, B, Morris, S, Waters, N, Gray, B, Macdonald, D, Macdonald, E, Parmar, MKB, Chandran, S & MND SMART Investigators 2024, 'Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial', The Lancet Neurology, vol. 23, no. 11, pp. 1097-1107. https://doi.org/10.1016/S1474-4422(24)00326-0

Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial. / Pal, Suvankar; Chataway, Jeremy; Swingler, Robert et al.
In: The Lancet Neurology, Vol. 23, No. 11, 01.11.2024, p. 1097-1107.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial

AU - Pal, Suvankar

AU - Chataway, Jeremy

AU - Swingler, Robert

AU - Macleod, Malcolm R

AU - Carragher, Neil O

AU - Hardingham, Giles

AU - Selvaraj, Bhuvaneish Thangaraj

AU - Smith, Colin

AU - Wong, Charis

AU - Newton, Judith

AU - Lyle, Dawn

AU - Stenson, Amy

AU - Dakin, Rachel S

AU - Ihenacho, Amarachi

AU - Colville, Shuna

AU - Mehta, Arpan R

AU - Stallard, Nigel

AU - Carpenter, James R

AU - Parker, Richard A

AU - Keerie, Catriona

AU - Weir, Christopher J

AU - Virgo, Bruce

AU - Morris, Stevie

AU - Waters, Nicola

AU - Gray, Beverley

AU - Macdonald, Donald

AU - Macdonald, Euan

AU - Parmar, Mahesh K B

AU - Chandran, Siddharthan

AU - MND SMART Investigators

AU - Gorrie, George

AU - Morrison, Ian

AU - Duncan, Callum

AU - Carod artal, Javier

AU - Williams, Timothy

AU - Srinivasan, Venkataramanan

AU - Radunovic, Aleksandar

AU - Pinto, Ashwin

AU - Hamdalla, Hisham

AU - Roberts, Rhys

AU - Garcia- reitboeck, Pablo

AU - Harrower, Timothy

AU - Mamutse, Godwin

AU - Crawley, Francesca

AU - Galton, Clare

AU - Dawson, Kenneth

AU - Forbes, Raeburn

AU - Hillier, Charles

AU - Mcdermott, Christopher

AU - Forbes, Deborah

AU - Bozkurt, Hatice

AU - Stavrou, Maria

AU - Kearns, Patrick

AU - Breen, David

AU - Kurucu king, Hatice

AU - Elliot, Elizabeth

AU - Beswick, Emily

AU - Williamson, Jill

AU - Cucurachi, Paolo

AU - Mclennan, Lucy

PY - 2024/11/1

Y1 - 2024/11/1

U2 - 10.1016/S1474-4422(24)00326-0

DO - 10.1016/S1474-4422(24)00326-0

M3 - Article

SN - 1474-4422

VL - 23

SP - 1097

EP - 1107

JO - The Lancet Neurology

JF - The Lancet Neurology

IS - 11

ER -

Pal S, Chataway J, Swingler R, Macleod MR , Carragher NO , Hardingham G et al. Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial. The Lancet Neurology. 2024 Nov 1;23(11):1097-1107. Epub 2024 Sept 19. doi: 10.1016/S1474-4422(24)00326-0