Salbutamol and salt-sensitive hypertension

Research output: Contribution to journalComment/debatepeer-review

Abstract / Description of output

Salbutamol activates NCC, the NaCl co-transporter of the distal convoluted tubule.
Salbutamol, in conjunction with high salt intake, induced hypertension in mice, rescued by thiazide therapy. Phospho-proteomics identified Protein Phosphatase 1/Inhibitor 1 as a distinct regulatory node for NCC activation by salbutamol, which did not activate the transporter in Inhibitor 1 knockout mice. Salbutamol is widely used in respiratory medicine and the acquisition of salt-sensitivity may be relevant to understanding cardiovascular risk in certain patients.
Original languageEnglish
JournalKidney International
Publication statusPublished - 1 Aug 2021


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