Salbutamol and salt-sensitive hypertension

Matthew A Bailey

doi:10.1016/j.kint.2021.05.023

Salbutamol and salt-sensitive hypertension

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Salbutamol activates NCC, the NaCl co-transporter of the distal convoluted tubule.
Salbutamol, in conjunction with high salt intake, induced hypertension in mice, rescued by thiazide therapy. Phospho-proteomics identified Protein Phosphatase 1/Inhibitor 1 as a distinct regulatory node for NCC activation by salbutamol, which did not activate the transporter in Inhibitor 1 knockout mice. Salbutamol is widely used in respiratory medicine and the acquisition of salt-sensitivity may be relevant to understanding cardiovascular risk in certain patients.

Original language	English
Journal	Kidney International
DOIs	https://doi.org/10.1016/j.kint.2021.05.023
Publication status	Published - 1 Aug 2021

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10.1016/j.kint.2021.05.023

Kidney InternationalAccepted author manuscript, 11.5 MB

https://www.kidney-international.org/article/S0085-2538(21)00566-4/fulltext

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title = "Salbutamol and salt-sensitive hypertension",

abstract = "Salbutamol activates NCC, the NaCl co-transporter of the distal convoluted tubule.Salbutamol, in conjunction with high salt intake, induced hypertension in mice, rescued by thiazide therapy. Phospho-proteomics identified Protein Phosphatase 1/Inhibitor 1 as a distinct regulatory node for NCC activation by salbutamol, which did not activate the transporter in Inhibitor 1 knockout mice. Salbutamol is widely used in respiratory medicine and the acquisition of salt-sensitivity may be relevant to understanding cardiovascular risk in certain patients.",

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year = "2021",

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N2 - Salbutamol activates NCC, the NaCl co-transporter of the distal convoluted tubule.Salbutamol, in conjunction with high salt intake, induced hypertension in mice, rescued by thiazide therapy. Phospho-proteomics identified Protein Phosphatase 1/Inhibitor 1 as a distinct regulatory node for NCC activation by salbutamol, which did not activate the transporter in Inhibitor 1 knockout mice. Salbutamol is widely used in respiratory medicine and the acquisition of salt-sensitivity may be relevant to understanding cardiovascular risk in certain patients.

AB - Salbutamol activates NCC, the NaCl co-transporter of the distal convoluted tubule.Salbutamol, in conjunction with high salt intake, induced hypertension in mice, rescued by thiazide therapy. Phospho-proteomics identified Protein Phosphatase 1/Inhibitor 1 as a distinct regulatory node for NCC activation by salbutamol, which did not activate the transporter in Inhibitor 1 knockout mice. Salbutamol is widely used in respiratory medicine and the acquisition of salt-sensitivity may be relevant to understanding cardiovascular risk in certain patients.

U2 - 10.1016/j.kint.2021.05.023

DO - 10.1016/j.kint.2021.05.023

M3 - Comment/debate

JO - Kidney International

JF - Kidney International

SN - 0085-2538

ER -

Salbutamol and salt-sensitive hypertension

Abstract

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