SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity

Maria Manali, Laura A Bissett, Julien A R Amat, Nicola Logan, Sam Scott, Ellen C Hughes, William T Harvey, Richard Orton, Emma C Thomson, Rory N Gunson, Mafalda Viana, Brian Willett, Pablo R Murcia

Research output: Contribution to journalArticlepeer-review

Abstract

Since the emergence of SARS-CoV-2, humans have been exposed to distinct SARS-CoV-2 antigens, either by infection with different variants, and/or vaccination. Population immunity is thus highly heterogeneous, but the impact of such heterogeneity on the effectiveness and breadth of the antibody-mediated response is unclear. We measured antibody-mediated neutralisation responses against SARS-CoV-2Wuhan, SARS-CoV-2α, SARS-CoV-2δ and SARS-CoV-2ο pseudoviruses using sera from patients with distinct immunological histories, including naive, vaccinated, infected with SARS-CoV-2Wuhan, SARS-CoV-2α or SARS-CoV-2δ, and vaccinated/infected individuals. We show that the breadth and potency of the antibody-mediated response is influenced by the number, the variant, and the nature (infection or vaccination) of exposures, and that individuals with mixed immunity acquired by vaccination and natural exposure exhibit the broadest and most potent responses. Our results suggest that the interplay between host immunity and SARS-CoV-2 evolution will shape the antigenicity and subsequent transmission dynamics of SARS-CoV-2, with important implications for future vaccine design.

Original languageEnglish
Article numberjiac332
JournalThe Journal of Infectious Diseases
Early online date3 Aug 2022
DOIs
Publication statusE-pub ahead of print - 3 Aug 2022

Fingerprint

Dive into the research topics of 'SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity'. Together they form a unique fingerprint.

Cite this