Projects per year
Abstract / Description of output
Population-level data on COVID-19 vaccine uptake in pregnancy and SARS-CoV-2 infection outcomes are lacking. We describe COVID-19 vaccine uptake and SARS-CoV-2 infection in pregnant women in Scotland, using whole-population data from a national, prospective cohort. Between the start of a COVID-19 vaccine program in Scotland, on 8 December 2020 and 31 October 2021, 25,917 COVID-19 vaccinations were given to 18,457 pregnant women. Vaccine coverage was substantially lower in pregnant women than in the general female population of 18-44 years; 32.3% of women giving birth in October 2021 had two doses of vaccine compared to 77.4% in all women. The extended perinatal mortality rate for women who gave birth within 28 d of a COVID-19 diagnosis was 22.6 per 1,000 births (95% CI 12.9-38.5; pandemic background rate 5.6 per 1,000 births; 452 out of 80,456; 95% CI 5.1-6.2). Overall, 77.4% (3,833 out of 4,950; 95% CI 76.2-78.6) of SARS-CoV-2 infections, 90.9% (748 out of 823; 95% CI 88.7-92.7) of SARS-CoV-2 associated with hospital admission and 98% (102 out of 104; 95% CI 92.5-99.7) of SARS-CoV-2 associated with critical care admission, as well as all baby deaths, occurred in pregnant women who were unvaccinated at the time of COVID-19 diagnosis. Addressing low vaccine uptake rates in pregnant women is imperative to protect the health of women and babies in the ongoing pandemic.
Original language | English |
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Pages (from-to) | 504-512 |
Number of pages | 512 |
Journal | Nature Medicine |
Volume | 28 |
Issue number | 3 |
DOIs | |
Publication status | Published - 13 Jan 2022 |
Keywords / Materials (for Non-textual outputs)
- COVID-19 Testing
- COVID-19 Vaccines/therapeutic use
- COVID-19/epidemiology
- Female
- Humans
- Pregnancy
- Pregnancy Complications, Infectious/epidemiology
- Pregnant Women
- Prospective Studies
- SARS-CoV-2
- Vaccination
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- 2 Finished
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COVID-19: Early Assessment of COVID-19 epidemiology and Vaccine/anti-viral Effectiveness (EAVE II)
1/04/20 → 30/09/22
Project: Research
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COVID-19: Early Assessment of COVID-19 epidemiology and Vaccine/anti-viral Effectiveness (EAVE II)
Simpson, C. & Sheikh, A.
1/04/20 → 30/09/21
Project: Research