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Abstract
The transport and trafficking of metabolites are critical for the correct functioning of live cells. However, in situ metabolic imaging studies are hampered by the lack of fluorescent chemical structures that allow direct monitoring of small metabolites under physiological conditions with high spatial and temporal resolution. Herein we describe SCOTfluors as novel small-sized multi-colored fluorophores for real-time tracking of essential metabolites in live cells and in vivo and for the acquisition of metabolic profiles from human cancer cells of variable origin.
Original language | English |
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Pages (from-to) | 6985-6989 |
Journal | Angewandte Chemie |
Volume | 131 |
Issue number | 21 |
Early online date | 28 Mar 2019 |
DOIs | |
Publication status | Published - 20 May 2019 |
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Dive into the research topics of 'SCOTfluors: Small, Conjugatable, Orthogonal and Tunable Fluorophores for in vivo Imaging of Cell Metabolism'. Together they form a unique fingerprint.Profiles
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C Simon Herrington
- Deanery of Molecular, Genetic and Population Health Sciences - Chair of Molecular Pathology of Cancer
- Edinburgh Pathology
- Edinburgh Cancer Research Centre
Person: Academic: Research Active
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Mathew Horrocks
- School of Chemistry - Lecturer in Biophysical Chemistry
Person: Academic: Research Active
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Marc Vendrell Escobar
- Deanery of Clinical Sciences - Personal Chair Translational Chemistry & Biomedical Imaging
- Centre for Inflammation Research
Person: Academic: Research Active