Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)

H K Ruben Thanacoody; Alasdair Gray; James W Dear; Judy Coyle; Euan A Sandilands; David J Webb; Steff Lewis; Michael Eddleston; Simon Hl Thomas; D Nicholas Bateman

doi:10.1186/2050-6511-14-20

Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)

H K Ruben Thanacoody, Alasdair Gray, James W Dear, Judy Coyle, Euan A Sandilands, David J Webb, Steff Lewis, Michael Eddleston, Simon Hl Thomas, D Nicholas Bateman

Research output: Contribution to journal › Article › peer-review

Abstract

Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen.

Original language	English
Pages (from-to)	20
Journal	BMC Pharmacology and Toxicology
Volume	14
DOIs	https://doi.org/10.1186/2050-6511-14-20
Publication status	Published - 4 Apr 2013

Keywords

Acetaminophen
Acetylcysteine
Anti-Inflammatory Agents, Non-Steroidal
Antiemetics
Double-Blind Method
Humans
Ondansetron
Scotland
Vomiting

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10.1186/2050-6511-14-20

Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)
© 2013 Thanacoody et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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MRC HUB NETWORK WORK
Murray, G.
MRC
1/01/09 → 31/08/15
Project: Research

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title = "Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)",

abstract = "Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen.",

keywords = "Acetaminophen, Acetylcysteine, Anti-Inflammatory Agents, Non-Steroidal, Antiemetics, Double-Blind Method, Humans, Ondansetron, Scotland, Vomiting",

author = "Thanacoody, {H K Ruben} and Alasdair Gray and Dear, {James W} and Judy Coyle and Sandilands, {Euan A} and Webb, {David J} and Steff Lewis and Michael Eddleston and Thomas, {Simon Hl} and Bateman, {D Nicholas}",

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doi = "10.1186/2050-6511-14-20",

language = "English",

volume = "14",

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journal = "BMC Pharmacology and Toxicology",

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publisher = "BioMed Central",

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Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP). / Thanacoody, H K Ruben; Gray, Alasdair ; Dear, James W; Coyle, Judy; Sandilands, Euan A; Webb, David J ; Lewis, Steff ; Eddleston, Michael; Thomas, Simon Hl; Bateman, D Nicholas.

In: BMC Pharmacology and Toxicology, Vol. 14, 04.04.2013, p. 20.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)

AU - Thanacoody, H K Ruben

AU - Gray, Alasdair

AU - Dear, James W

AU - Coyle, Judy

AU - Sandilands, Euan A

AU - Webb, David J

AU - Lewis, Steff

AU - Eddleston, Michael

AU - Thomas, Simon Hl

AU - Bateman, D Nicholas

PY - 2013/4/4

Y1 - 2013/4/4

N2 - Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen.

AB - Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen.

KW - Acetaminophen

KW - Acetylcysteine

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Antiemetics

KW - Double-Blind Method

KW - Humans

KW - Ondansetron

KW - Scotland

KW - Vomiting

U2 - 10.1186/2050-6511-14-20

DO - 10.1186/2050-6511-14-20

M3 - Article

C2 - 23556549

VL - 14

SP - 20

JO - BMC Pharmacology and Toxicology

JF - BMC Pharmacology and Toxicology

SN - 2050-6511

ER -

Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)

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Keywords

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