Scottish and Newcastle antiemetic pre-treatment for paracetamol poisoning study (SNAP)

H K Ruben Thanacoody, Alasdair Gray, James W Dear, Judy Coyle, Euan A Sandilands, David J Webb, Steff Lewis, Michael Eddleston, Simon Hl Thomas, D Nicholas Bateman

Research output: Contribution to journalArticlepeer-review

Abstract

Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen.
Original languageEnglish
Pages (from-to)20
JournalBMC Pharmacology and Toxicology
Volume14
DOIs
Publication statusPublished - 4 Apr 2013

Keywords

  • Acetaminophen
  • Acetylcysteine
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antiemetics
  • Double-Blind Method
  • Humans
  • Ondansetron
  • Scotland
  • Vomiting

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