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Abstract
Paracetamol (acetaminophen) poisoning remains the commonest cause of acute liver injury in Europe and North America. The intravenous (IV) N-acetylcysteine (NAC) regimen introduced in the 1970s has continued effectively unchanged. This involves 3 different infusion regimens (dose and time) lasting over 20 hours. The same weight-related dose of NAC is used irrespective of paracetamol dose. Complications include frequent nausea and vomiting, anaphylactoid reactions and dosing errors. We designed a randomised controlled study investigating the efficacy of antiemetic pre-treatment (ondansetron) using standard NAC and a modified, shorter, regimen.
Original language | English |
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Pages (from-to) | 20 |
Journal | BMC Pharmacology and Toxicology |
Volume | 14 |
DOIs | |
Publication status | Published - 4 Apr 2013 |
Keywords
- Acetaminophen
- Acetylcysteine
- Anti-Inflammatory Agents, Non-Steroidal
- Antiemetics
- Double-Blind Method
- Humans
- Ondansetron
- Scotland
- Vomiting
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