Scrapie: uncertainties, biology and molecular approaches

Nora Hunter

Research output: Contribution to journalArticlepeer-review

Abstract

The study of the biology of scrapie in sheep is irretrievably associated with the genetics of the PrP gene in sheep. Control of susceptibility and resistance is so closely linked to certain alleles of the sheep PrP gene that no review on scrapie can avoid PrP genetics. Before the importance of PrP protein was discovered and before the influence of the gene itself on disease incidence was understood, it was clear there were some sheep which were more susceptible to natural scrapie than others and that this feature was heritable. These early observations have led to the development and use of PrP genotyping in sheep in what is probably the biggest genetic selection process ever attempted. The accompanying increase in surveillance has also discovered a novel type of scrapie, the subject of much speculation about its origin.
Original languageEnglish
Pages (from-to)619-28
Number of pages10
JournalBBA - Bioenergetics
Volume1772
Issue number6
DOIs
Publication statusPublished - Jun 2007

Keywords

  • Animals
  • Cattle
  • Encephalopathy, Bovine Spongiform
  • Genetic Predisposition to Disease
  • Genotype
  • Prions
  • Scrapie
  • Sheep

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