Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

Nina Svensen; Juan Jose Diaz-Mochon; Kevin Dhaliwal; Songsak Planonth; Michael Dewar; J. Douglas Armstrong; Mark Bradley

doi:10.1002/anie.201101804

Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

Nina Svensen, Juan Jose Diaz-Mochon, Kevin Dhaliwal, Songsak Planonth, Michael Dewar, J. Douglas Armstrong, Mark Bradley

Research output: Contribution to journal › Article › peer-review

Abstract

The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell-selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)-encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest.

Original language	English
Pages (from-to)	6133-6136
Number of pages	4
Journal	Angewandte Chemie International Edition
Volume	50
Issue number	27
DOIs	https://doi.org/10.1002/anie.201101804
Publication status	Published - Jun 2011

Keywords / Materials (for Non-textual outputs)

drug delivery
homing peptides
microarrays
peptide nucleic acids
peptides
PENETRATING-PEPTIDE
PHENOTYPIC HETEROGENEITY
FLOW-CYTOMETRY
DRUG-DELIVERY
TAT PEPTIDE
CELLS
LEUKEMIA
MOUSE
GENE
LINE

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10.1002/anie.201101804

http://onlinelibrary.wiley.com/doi/10.1002/anie.201101804/abstract

Cite this

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title = "Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery",

abstract = "The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell-selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)-encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest.",

keywords = "drug delivery, homing peptides, microarrays, peptide nucleic acids, peptides, PENETRATING-PEPTIDE, PHENOTYPIC HETEROGENEITY, FLOW-CYTOMETRY, DRUG-DELIVERY, TAT PEPTIDE, CELLS, LEUKEMIA, MOUSE, GENE, LINE",

author = "Nina Svensen and Diaz-Mochon, {Juan Jose} and Kevin Dhaliwal and Songsak Planonth and Michael Dewar and Armstrong, {J. Douglas} and Mark Bradley",

year = "2011",

month = jun,

doi = "10.1002/anie.201101804",

language = "English",

volume = "50",

pages = "6133--6136",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

publisher = "Wiley-VCH",

number = "27",

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TY - JOUR

T1 - Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

AU - Svensen, Nina

AU - Diaz-Mochon, Juan Jose

AU - Dhaliwal, Kevin

AU - Planonth, Songsak

AU - Dewar, Michael

AU - Armstrong, J. Douglas

AU - Bradley, Mark

PY - 2011/6

Y1 - 2011/6

N2 - The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell-selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)-encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest.

AB - The identification of peptides to optimize both the delivery and tumor penetration of existing cancer drugs in a cell-selective manner would be highly desirable. The screening of a peptide nucleic acid (PNA)-encoded peptide library (see picture) now allows the identification of versatile cell homing peptides for any cell type of interest.

KW - drug delivery

KW - homing peptides

KW - microarrays

KW - peptide nucleic acids

KW - peptides

KW - PENETRATING-PEPTIDE

KW - PHENOTYPIC HETEROGENEITY

KW - FLOW-CYTOMETRY

KW - DRUG-DELIVERY

KW - TAT PEPTIDE

KW - CELLS

KW - LEUKEMIA

KW - MOUSE

KW - GENE

KW - LINE

UR - http://www.scopus.com/inward/record.url?scp=79959517842&partnerID=8YFLogxK

U2 - 10.1002/anie.201101804

DO - 10.1002/anie.201101804

M3 - Article

SN - 1433-7851

VL - 50

SP - 6133

EP - 6136

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 27

ER -

Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

Abstract

Keywords / Materials (for Non-textual outputs)

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Post-Coded Ligands for Cell Sorting and Delivery

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Screening of a Combinatorial Homing Peptide Library for Selective Cellular Delivery

Abstract

Keywords / Materials (for Non-textual outputs)

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Other files and links

Fingerprint

Projects

Post-Coded Ligands for Cell Sorting and Delivery

Cite this