Screening with magnetic resonance imaging and mammography of a UK population at high familial risk of breast cancer: a prospective multicentre cohort study (MARIBS)

M O Leach, C R M Boggis, A K Dixon, D F Easton, R A Eeles, D G R Evans, F J Gilbert, I Griebsch, R J C Hoff, P Kessar, S R Lakhani, S M Moss, A Nerurkar, A R Padhani, L J Pointon, D Thompson, R M L Warren, MARIBS study group, MIchael Dixon

Research output: Contribution to journalArticlepeer-review

Abstract

Women genetically predisposed to breast cancer often develop the disease at a young age when dense breast tissue reduces the sensitivity of X-ray mammography. Our aim was, therefore, to compare contrast enhanced magnetic resonance imaging (CE MRI) with mammography for screening.
Original languageEnglish
Pages (from-to)1769-78
Number of pages10
JournalThe Lancet
Volume365
Issue number9473
DOIs
Publication statusPublished - 2005

Keywords

  • Adult
  • Breast Neoplasms
  • Carcinoma, Intraductal, Noninfiltrating
  • Cohort Studies
  • Contrast Media
  • Female
  • Gadolinium DTPA
  • Genes, BRCA1
  • Genes, BRCA2
  • Genes, p53
  • Genetic Predisposition to Disease
  • Humans
  • Magnetic Resonance Imaging
  • Mammography
  • Middle Aged
  • Mutation
  • Predictive Value of Tests
  • ROC Curve
  • Sensitivity and Specificity

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