Secretome of human aortic valves

Fernando de la Cuesta, Gloria Alvarez-Llamas, Felix Gil-Dones, Verónica M Darde, Enrique Calvo, Juan Antonio López, Fernando Vivanco, María G Barderas

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract / Description of output

One of the major challenges in cardiovascular medicine is to identify candidate biomarker proteins. Between different proteomics studies, the secretome is a valuable tool in the search for biomarkers locally released by a studied tissue and remains particularly important while working with vascular tissues, since the secreted proteins would be probably shed to the blood. In this chapter, we described a method to validate the origin of secreted proteins in human aortic valves, demonstrating their synthesis and release by the tissue and ruling out blood origin.

Original languageEnglish
Title of host publicationHeart Proteomics
Number of pages7
Publication statusPublished - 2013

Keywords / Materials (for Non-textual outputs)

  • Aortic Valve
  • Aortic Valve Stenosis
  • Chromatography, Liquid
  • Culture Media, Conditioned
  • Humans
  • Peptide Fragments
  • Peptide Mapping
  • Proteolysis
  • Proteome
  • Tandem Mass Spectrometry
  • Tissue Culture Techniques
  • Trypsin


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