Selected Ion Flow Tube-Mass Spectrometry (SIFT-MS) as an Alternative to Gas Chromatography/Mass Spectrometry (GC/MS) for the Analysis of Cyclohexanone and Cyclohexanol in Plasma

Colin Hastie, Adrian Thompson, Mark Perkins, Vaughan S. Langford, Michael Eddleston, Natalie Z M Homer

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Self-poisoning with professional agricultural pesticide products is responsible for about 20% of global suicide, with most cases occurring in South Asia and China. Treatment of severe poisoning involves long-term intensive clinical care and is often unsuccessful. Solvent co-formulants (such as cyclohexanone) also
contribute to mortality themselves or via more toxic metabolic
products (such as cyclohexanol). Faster detection of co-formulants
could aid earlier identification of pesticide poisoning and faster
intervention, reducing mortality. Conventional analysis of volatiles
in blood uses headspace (HS)-GC/MS. This paper evaluates SIFTMS, a direct MS technique that provides higher sample throughput
than GC/MS, as a potential tool for cyclohexanone and
cyclohexanol analysis in plasma. Both instruments were calibrated
using a conventional approach prior to analysis of each porcine
plasma sample on both instruments. Comparative data were evaluated using Bland−Altman plots, demonstrating that the techniques
were in good agreement. Compared with GC/MS, SIFT-MS provides fourfold higher sample throughput and shows great promise as
an alternative analytical tool.
Original languageEnglish
JournalACS Omega
DOIs
Publication statusPublished - 19 Nov 2021

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