Abstract / Description of output
The mono ortho-bromination of phenolic building blocks by NBS has been achieved in short reaction times (15-20 min) using ACS-grade methanol as a solvent. The reactions can be conducted on phenol, naphthol and biphenol substrates, giving yields of >86% on gram scale. Excellent selectivity for the desired mono ortho-brominated products is achieved in the presence of 10 mol % para-TsOH, and the reaction is shown to be tolerant of a range of substituents, including CH₃, F, and NHBoc.
Original language | English |
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Number of pages | 8 |
Journal | Molecules |
Volume | 21 |
Issue number | 1 |
DOIs | |
Publication status | Published - 13 Jan 2016 |