Selective breeding for susceptibility to myopia reveals a gene-environment interaction

Y. P. Chen; P. M. Hocking; L. Wang; B. Povazay; A. Prashar; C. H. To; J. T. Erichsen; M. Feldkaemper; B. Hofer; W. Drexler; F. Schaeffel; J. A. Guggenheim

doi:10.1167/iovs.10-7044

Selective breeding for susceptibility to myopia reveals a gene-environment interaction

Y. P. Chen, P. M. Hocking, L. Wang, B. Povazay, A. Prashar, C. H. To, J. T. Erichsen, M. Feldkaemper, B. Hofer, W. Drexler, F. Schaeffel, J. A. Guggenheim

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To test whether the inter-animal variability in susceptibility to visually-induced myopia is genetically determined. Methods: Monocular deprivation of sharp vision (DSV) was induced in outbred White Leghorn chicks aged 4 days old. After 4 days DSV, myopia susceptibility was quantified by the relative changes in axial length and refraction. Chicks in the extreme tails of the distribution of susceptibility to DSV were kept and paired for breeding (High susceptibility and Low susceptibility lines). A second round of selection was then carried out as above. The third generation of chicks, derived from the selected parents, was assessed after either monocular DSV (4 or 10 days) or lens wear. Results: After two rounds of selective breeding, chicks from the High susceptibility line developed approximately twice as much myopia in response to 4 days DSV as those from the Low susceptibility line (P

Original language	English
Pages (from-to)	4003-4011
Number of pages	9
Journal	Investigative Ophthalmology & Visual Science (IOVS)
Volume	52
Issue number	7
DOIs	https://doi.org/10.1167/iovs.10-7044
Publication status	Published - Jun 2011

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Chen, Y. P., Hocking, P. M., Wang, L., Povazay, B., Prashar, A., To, C. H., Erichsen, J. T., Feldkaemper, M., Hofer, B., Drexler, W., Schaeffel, F., & Guggenheim, J. A. (2011). Selective breeding for susceptibility to myopia reveals a gene-environment interaction. Investigative Ophthalmology & Visual Science (IOVS), 52(7), 4003-4011. https://doi.org/10.1167/iovs.10-7044

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title = "Selective breeding for susceptibility to myopia reveals a gene-environment interaction",

abstract = "Purpose: To test whether the inter-animal variability in susceptibility to visually-induced myopia is genetically determined. Methods: Monocular deprivation of sharp vision (DSV) was induced in outbred White Leghorn chicks aged 4 days old. After 4 days DSV, myopia susceptibility was quantified by the relative changes in axial length and refraction. Chicks in the extreme tails of the distribution of susceptibility to DSV were kept and paired for breeding (High susceptibility and Low susceptibility lines). A second round of selection was then carried out as above. The third generation of chicks, derived from the selected parents, was assessed after either monocular DSV (4 or 10 days) or lens wear. Results: After two rounds of selective breeding, chicks from the High susceptibility line developed approximately twice as much myopia in response to 4 days DSV as those from the Low susceptibility line (P",

author = "Chen, {Y. P.} and Hocking, {P. M.} and L. Wang and B. Povazay and A. Prashar and To, {C. H.} and Erichsen, {J. T.} and M. Feldkaemper and B. Hofer and W. Drexler and F. Schaeffel and Guggenheim, {J. A.}",

year = "2011",

month = jun,

doi = "10.1167/iovs.10-7044",

language = "English",

volume = "52",

pages = "4003--4011",

journal = "Investigative Ophthalmology & Visual Science (IOVS)",

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T1 - Selective breeding for susceptibility to myopia reveals a gene-environment interaction

AU - Chen, Y. P.

AU - Hocking, P. M.

AU - Wang, L.

AU - Povazay, B.

AU - Prashar, A.

AU - To, C. H.

AU - Erichsen, J. T.

AU - Feldkaemper, M.

AU - Hofer, B.

AU - Drexler, W.

AU - Schaeffel, F.

AU - Guggenheim, J. A.

PY - 2011/6

Y1 - 2011/6

N2 - Purpose: To test whether the inter-animal variability in susceptibility to visually-induced myopia is genetically determined. Methods: Monocular deprivation of sharp vision (DSV) was induced in outbred White Leghorn chicks aged 4 days old. After 4 days DSV, myopia susceptibility was quantified by the relative changes in axial length and refraction. Chicks in the extreme tails of the distribution of susceptibility to DSV were kept and paired for breeding (High susceptibility and Low susceptibility lines). A second round of selection was then carried out as above. The third generation of chicks, derived from the selected parents, was assessed after either monocular DSV (4 or 10 days) or lens wear. Results: After two rounds of selective breeding, chicks from the High susceptibility line developed approximately twice as much myopia in response to 4 days DSV as those from the Low susceptibility line (P

AB - Purpose: To test whether the inter-animal variability in susceptibility to visually-induced myopia is genetically determined. Methods: Monocular deprivation of sharp vision (DSV) was induced in outbred White Leghorn chicks aged 4 days old. After 4 days DSV, myopia susceptibility was quantified by the relative changes in axial length and refraction. Chicks in the extreme tails of the distribution of susceptibility to DSV were kept and paired for breeding (High susceptibility and Low susceptibility lines). A second round of selection was then carried out as above. The third generation of chicks, derived from the selected parents, was assessed after either monocular DSV (4 or 10 days) or lens wear. Results: After two rounds of selective breeding, chicks from the High susceptibility line developed approximately twice as much myopia in response to 4 days DSV as those from the Low susceptibility line (P

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U2 - 10.1167/iovs.10-7044

DO - 10.1167/iovs.10-7044

M3 - Article

SN - 0146-0404

VL - 52

SP - 4003

EP - 4011

JO - Investigative Ophthalmology & Visual Science (IOVS)

JF - Investigative Ophthalmology & Visual Science (IOVS)

IS - 7

ER -

Selective breeding for susceptibility to myopia reveals a gene-environment interaction

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