Selective breeding for susceptibility to myopia reveals a gene-environment interaction

Y. P. Chen, P. M. Hocking, L. Wang, B. Povazay, A. Prashar, C. H. To, J. T. Erichsen, M. Feldkaemper, B. Hofer, W. Drexler, F. Schaeffel, J. A. Guggenheim

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Purpose: To test whether the inter-animal variability in susceptibility to visually-induced myopia is genetically determined. Methods: Monocular deprivation of sharp vision (DSV) was induced in outbred White Leghorn chicks aged 4 days old. After 4 days DSV, myopia susceptibility was quantified by the relative changes in axial length and refraction. Chicks in the extreme tails of the distribution of susceptibility to DSV were kept and paired for breeding (High susceptibility and Low susceptibility lines). A second round of selection was then carried out as above. The third generation of chicks, derived from the selected parents, was assessed after either monocular DSV (4 or 10 days) or lens wear. Results: After two rounds of selective breeding, chicks from the High susceptibility line developed approximately twice as much myopia in response to 4 days DSV as those from the Low susceptibility line (P
Original languageEnglish
Pages (from-to)4003-4011
Number of pages9
JournalInvestigative Ophthalmology & Visual Science (IOVS)
Issue number7
Publication statusPublished - Jun 2011


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