Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish

Aryan Kaveh; Finnius Bruton; Magdalena Oremek; Carl S. Tucker; Jonathan M. Taylor; John J Mullins; Adriano G Rossi; Martin A Denvir

doi:10.1242/dev.199636

Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish

Aryan Kaveh^*, Finnius Bruton, Magdalena Oremek, Carl S. Tucker, Jonathan M. Taylor, John J Mullins, Adriano G Rossi, Martin A Denvir

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Development
DOIs	https://doi.org/10.1242/dev.199636
Publication status	Published - 15 Sept 2021

Keywords / Materials (for Non-textual outputs)

cardiac
regeneration
zebrafish
AT7519
neutrophil
resolution

Access to Document

10.1242/dev.199636

DEVELOP-2021-199636v2-KavehAccepted author manuscript, 8.43 MB

Role of CDK9 in zebrafish heart repair and regeneration following resolution of inflammation
Denvir, M. (Principal Investigator)
UK-based charities
1/08/17 → 31/07/21
Project: Research
BHF RESEARCH EXCELLENCE AWARD (GRANT2)
Mullins, J. (Principal Investigator)
UK-based charities
1/06/15 → 31/05/16
Project: Research
The role of cyclin-dependent kinase-9 inhibition in promoting the resolution of chronic inflammation
Rossi, A. (Principal Investigator) & Haslett, C. (Co-investigator)
MRC
1/05/13 → 30/10/19
Project: Research

Cite this

@article{1460e981492c43e6bb6087356bea9118,

title = "Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish",

keywords = "cardiac, regeneration, zebrafish, AT7519, neutrophil, resolution",

author = "Aryan Kaveh and Finnius Bruton and Magdalena Oremek and Tucker, {Carl S.} and Taylor, {Jonathan M.} and Mullins, {John J} and Rossi, {Adriano G} and Denvir, {Martin A}",

year = "2021",

month = sep,

day = "15",

doi = "10.1242/dev.199636",

language = "English",

journal = "Development",

issn = "0950-1991",

publisher = "Company of Biologists Ltd",

}

TY - JOUR

T1 - Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish

AU - Kaveh, Aryan

AU - Bruton, Finnius

AU - Oremek, Magdalena

AU - Tucker, Carl S.

AU - Taylor, Jonathan M.

AU - Mullins, John J

AU - Rossi, Adriano G

AU - Denvir, Martin A

PY - 2021/9/15

Y1 - 2021/9/15

KW - cardiac

KW - regeneration

KW - zebrafish

KW - AT7519

KW - neutrophil

KW - resolution

U2 - 10.1242/dev.199636

DO - 10.1242/dev.199636

M3 - Article

SN - 0950-1991

JO - Development

JF - Development

ER -

Selective CDK9 inhibition resolves neutrophilic inflammation and enhances cardiac regeneration in larval zebrafish

Keywords / Materials (for Non-textual outputs)

Access to Document

Projects

Role of CDK9 in zebrafish heart repair and regeneration following resolution of inflammation

BHF RESEARCH EXCELLENCE AWARD (GRANT2)

The role of cyclin-dependent kinase-9 inhibition in promoting the resolution of chronic inflammation

Cite this