Selective sweeps under dominance and inbreeding

Matthew Hartfield, Thomas Bataillon

Research output: Contribution to journalArticlepeer-review

Abstract

A major research goal in evolutionary genetics is to uncover loci experiencing positive selection. One approach involves finding 'selective sweeps' patterns, which can either be 'hard sweeps' formed by de novo mutation, or 'soft sweeps' arising from recurrent mutation or existing standing variation. Existing theory generally assumes outcrossing populations, and it is unclear how dominance affects soft sweeps. We consider how arbitrary dominance and inbreeding via self-fertilisation affect hard and soft sweep signatures. With increased self-fertilisation, they are maintained over longer map distances due to reduced effective recombination and faster beneficial allele fixation times. Dominance can affect sweep patterns in outcrossers if the derived variant originates from either a single novel allele, or from recurrent mutation. These models highlight the challenges in distinguishing hard and soft sweeps, and propose methods to differentiate between scenarios.
Original languageEnglish
Pages (from-to)1063-1075
JournalG3: Genes | Genomes | Genetics
Volume10
Issue number3
Early online date23 Jan 2020
DOIs
Publication statusPublished - 1 Mar 2020

Keywords

  • adaptation
  • dominance
  • Self-fertilisation
  • selective sweeps
  • population genetics

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