Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage

Leigh Campbell; Forbes Howie; John R Arthur; Fergus Nicol; Geoffrey Beckett

doi:10.1016/j.nut.2006.10.006

Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage

Leigh Campbell, Forbes Howie, John R Arthur, Fergus Nicol, Geoffrey Beckett

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

We examined the ability of sulforaphane and selenium to modify the expression of thioredoxin reductase (TR-1) and the glutathione peroxidases (GPX-1 and GPX-4) in EAhy926 cells. The effectiveness of these agents to protect cells against peroxidative damage was also assessed.

Original language	English
Pages (from-to)	138-44
Number of pages	7
Journal	Nutrition
Volume	23
Issue number	2
DOIs	https://doi.org/10.1016/j.nut.2006.10.006
Publication status	Published - 2007

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title = "Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage",

abstract = "We examined the ability of sulforaphane and selenium to modify the expression of thioredoxin reductase (TR-1) and the glutathione peroxidases (GPX-1 and GPX-4) in EAhy926 cells. The effectiveness of these agents to protect cells against peroxidative damage was also assessed.",

author = "Leigh Campbell and Forbes Howie and Arthur, {John R} and Fergus Nicol and Geoffrey Beckett",

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T1 - Selenium and sulforaphane modify the expression of selenoenzymes in the human endothelial cell line EAhy926 and protect cells from oxidative damage

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AU - Howie, Forbes

AU - Arthur, John R

AU - Nicol, Fergus

AU - Beckett, Geoffrey

PY - 2007

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N2 - We examined the ability of sulforaphane and selenium to modify the expression of thioredoxin reductase (TR-1) and the glutathione peroxidases (GPX-1 and GPX-4) in EAhy926 cells. The effectiveness of these agents to protect cells against peroxidative damage was also assessed.

AB - We examined the ability of sulforaphane and selenium to modify the expression of thioredoxin reductase (TR-1) and the glutathione peroxidases (GPX-1 and GPX-4) in EAhy926 cells. The effectiveness of these agents to protect cells against peroxidative damage was also assessed.

U2 - 10.1016/j.nut.2006.10.006

DO - 10.1016/j.nut.2006.10.006

M3 - Article

C2 - 17150329

VL - 23

SP - 138

EP - 144

JO - Nutrition

JF - Nutrition

SN - 0899-9007

IS - 2

ER -