Self-Assembly of Disorazole C1 through a One-Pot Alkyne Metathesis Homodimerization Strategy

Kevin J. Ralston, H. Clinton Ramstadius, Richard C. Brewster, Helen S. Niblock, Alison N. Hulme

Research output: Contribution to journalArticlepeer-review

Abstract

Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.
Original languageEnglish
Pages (from-to)7086-7090
Number of pages5
JournalAngewandte Chemie International Edition
Volume54
Issue number24
Early online date29 Apr 2015
DOIs
Publication statusPublished - 8 Jun 2015

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