Self-Assembly of Disorazole C1 through a One-Pot Alkyne Metathesis Homodimerization Strategy

Kevin J. Ralston; H. Clinton Ramstadius; Richard C. Brewster; Helen S. Niblock; Alison N. Hulme

doi:10.1002/anie.201501922

Self-Assembly of Disorazole C1 through a One-Pot Alkyne Metathesis Homodimerization Strategy

Kevin J. Ralston, H. Clinton Ramstadius, Richard C. Brewster, Helen S. Niblock, Alison N. Hulme

Research output: Contribution to journal › Article › peer-review

Abstract

Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

Original language	English
Pages (from-to)	7086-7090
Number of pages	5
Journal	Angewandte Chemie International Edition
Volume	54
Issue number	24
Early online date	29 Apr 2015
DOIs	https://doi.org/10.1002/anie.201501922
Publication status	Published - 8 Jun 2015

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http://doi.wiley.com/10.1002/anie.201501922

Alison Hulme
- School of Chemistry - Personal Chair of Synthesis and Chemical Biology
- EaStCHEM
Person: Academic: Research Active

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title = "Self-Assembly of Disorazole C1 through a One-Pot Alkyne Metathesis Homodimerization Strategy",

abstract = "Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.",

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AU - Ralston, Kevin J.

AU - Ramstadius, H. Clinton

AU - Brewster, Richard C.

AU - Niblock, Helen S.

AU - Hulme, Alison N.

PY - 2015/6/8

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AB - Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.

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Self-Assembly of Disorazole C1 through a One-Pot Alkyne Metathesis Homodimerization Strategy

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