Self-Reported Decline in Everyday Function, Cognitive Symptoms, and Cognitive Function in People With HIV.

R. Laverick, L. Haddow, M. Daskalopoulou, F. Lampe, R. Gilson, A. Speakman, A. Antinori, T. Bruun, A. Vassilenko, S. Collins, A. Rodger, Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group

Research output: Contribution to journalArticlepeer-review

Abstract

We determined factors associated with self-reported decline in activities of daily living (ADLs) and symptoms of cognitive impairment in HIV positive adults in 5 European clinics.HIV+ adults underwent computerized and pen-and-paper neuropsychological tests and questionnaires of cognitive symptoms and ADLs. We considered cognitive function in 5 domains, psychosocial factors, and clinical parameters as potentially associated with symptoms. Separate regression analyses were used to determine factors associated with a decline in ADL (defined as self-reported decline affecting ≥2 ADLs and attributed to cognitive difficulties) and self-reported frequency of symptoms of cognitive impairment. We also estimated the diagnostic accuracy of both questionnaires as tests for cognitive impairment.Four hundred forty-eight patients completed the assessments [mean age 45.8 years, 84% male, 87% white, median CD4 count 550 cells/mm, median time since HIV diagnosis 9.9 years, 81% virologically suppressed (HIV-1 plasma RNA
Original languageEnglish
Pages (from-to)e74-e83
JournalJournal of Acquired Immune Deficiency Syndromes
Volume76
Issue number3
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • Cognitive Impairment in People with HIV in the European Region (CIPHER) Study Group
  • Humans
  • HIV Infections
  • Activities of Daily Living
  • Risk Factors
  • Regression Analysis
  • Cognition
  • Cognition Disorders
  • Neuropsychological Tests
  • Adult
  • Middle Aged
  • Female
  • Male

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