Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway

S Battersby, K J Sales, A R Williams, R A Anderson, S Gardner, H N Jabbour

Research output: Contribution to journalArticlepeer-review

Abstract

Prostaglandin E(2) (PGE(2)) has been shown to modulate angiogenesis and tumour progression via the E-series prostanoid-2 (EP2) receptor. Endometrial adenocarcinomas may be exposed to endogenous PGE(2) and exogenous PGE(2), present at high concentration in seminal plasma.
Original languageEnglish
Pages (from-to)36-44
Number of pages9
JournalHuman Reproduction
Volume22
Issue number1
DOIs
Publication statusPublished - 2007

Keywords

  • Endometrial carcinoma
  • E-series prostanoid receptor 2
  • Fibroblast Growth Factor 2
  • SEMINAL PLASMA

Fingerprint

Dive into the research topics of 'Seminal plasma and prostaglandin E2 up-regulate fibroblast growth factor 2 expression in endometrial adenocarcinoma cells via E-series prostanoid-2 receptor-mediated transactivation of the epidermal growth factor receptor and extracellular signal-regulated kinase pathway'. Together they form a unique fingerprint.

Cite this