Senescence: a new weapon for cancer therapy

Juan Carlos Acosta, Jesús Gil

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Senescence is a stable cell cycle arrest that can be activated by oncogenic signaling and manifests with changes in cellular organization and gene expression, such as the induction of a complex secretome. Importantly, senescence limits tumor progression and determines the outcome of conventional anticancer therapies. In recent years, therapeutic approaches such as p53 reactivation, inhibition of c-MYC in addicted tumors or treatment with cyclin-dependent kinase (CDK) inhibitors have proven effective by invoking a senescence response. The possibility of using prosenescence therapies for cancer treatment has provoked considerable interest. We propose that the senescence secretome can be a source of novel targets for prosenescence therapies, as it has tumor suppressive actions. Overall, tailored prosenescence therapies have the potential to be used for treating cancer and other pathologies.
Original languageEnglish
Pages (from-to)211-9
Number of pages9
JournalTrends In Cell Biology
Issue number4
Publication statusPublished - Apr 2012

Keywords / Materials (for Non-textual outputs)

  • Phenotype
  • Animals
  • Neoplasms
  • Cell Aging
  • Humans
  • Aging
  • Disease Progression


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