Senescence Associated Heterochromatic Foci: SAHF

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract / Description of output

Abstract The permanent cell cycle exit known as cellular senescence is a stress response
that can be triggered by DNA damage, telomere erosion and activation of oncogenic
signalling. Increasing evidence suggests that cellular senescence in cell culture mimics an
in vivo situation, where a pathological cue (like the activation of an oncogene) triggers
senescence as an intrinsic tumour suppressor defence. Oncogene induced senescence
(OIS) is often accompanied by a global change in nuclear architecture, most dramatically
Original languageEnglish
Title of host publicationThe Functional Nucleus
PublisherSpringer
Pages205
Publication statusPublished - 2016

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