Separating the isomers-Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B

Aurélie Brunet, Tashfeen Aslam, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract

Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.

Original languageEnglish
Pages (from-to)3186-3188
Number of pages3
JournalBioorganic & Medicinal Chemistry Letters
Volume24
Issue number14
DOIs
Publication statusPublished - 15 Jul 2014

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