Separating the isomers-Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B

Aurélie Brunet; Tashfeen Aslam; Mark Bradley

doi:10.1016/j.bmcl.2014.04.090

Separating the isomers-Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B

Aurélie Brunet, Tashfeen Aslam, Mark Bradley

Research output: Contribution to journal › Article › peer-review

Abstract

Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.

Original language	English
Pages (from-to)	3186-3188
Number of pages	3
Journal	Bioorganic & Medicinal Chemistry Letters
Volume	24
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2014.04.090
Publication status	Published - 15 Jul 2014

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10.1016/j.bmcl.2014.04.090

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title = "Separating the isomers-Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B",

abstract = "Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.",

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AU - Brunet, Aurélie

AU - Aslam, Tashfeen

AU - Bradley, Mark

PY - 2014/7/15

Y1 - 2014/7/15

N2 - Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.

AB - Diacetate protection of 5 and 6-carboxyfluorescein followed by synthesis of the N-hydroxysuccinimide esters allowed ready separation of the two isomers on a multi-gram scale. The 5 and 6-carboxyrhodamine B N-hydroxysuccinimide esters were also readily synthesised and separated.

U2 - 10.1016/j.bmcl.2014.04.090

DO - 10.1016/j.bmcl.2014.04.090

M3 - Article

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SN - 0960-894X

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JO - Bioorganic & Medicinal Chemistry Letters

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ER -

Separating the isomers-Efficient synthesis of the N-hydroxysuccinimide esters of 5 and 6-carboxyfluorescein diacetate and 5 and 6-carboxyrhodamine B

Abstract

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